Independently predictive prognostic variables after resection for colorectal carcinoma

The Australian and New Zealand Journal of Surgery
J E Payne, H J Meyer

Abstract

Clinical variables such as surgical morbidity, comorbidity and follow-up have been claimed to influence ultimate survival in patients who have resection for colorectal cancer. It is unclear whether the effect of clinical covariates is confounding or independent. We have attempted to build a comprehensive model, which is capable of testing the dependence and importance of prognostic factors. A consecutive series of patients admitted between 1970 and 1988 and followed until 1992 had data recorded about presentation, pathology, hospitalization, aftercare and long-term outcome. The patients were also divided into two approximately equal groups that were cared for by one and seven surgeons, respectively. Clinical and pathological covariates were built into a Cox (multivariate) proportional hazard model of crude survival. This was achieved with the SPSS advanced statistical package version 6.1. Comparison between groups was then performed of clinical and pathological factors and subsequent cancer management. There were 207 patients whose average age was 75 years, median survival was 43 months and operative mortality was 4%. The Cox model was robust. Covariates that had independent survival effects were pathological stage (P = 0.0000)...Continue Reading

References

Dec 1, 1992·The Australian and New Zealand Journal of Surgery·J A McLeishV Thursfield
Mar 24, 1991·The New England Journal of Medicine·G Steele
Nov 1, 1989·The British Journal of Surgery·D J JonesP F Schofield
Apr 1, 1989·Diseases of the Colon and Rectum·J E Payne
Sep 1, 1987·The Australian and New Zealand Journal of Surgery·J E PayneP H Chapuis
Nov 1, 1986·Diseases of the Colon and Rectum·J E PayneM T Pheils
Dec 1, 1985·The Australian and New Zealand Journal of Surgery·J E Payne
Jan 1, 1984·The British Journal of Surgery·R K PhillipsL P Fielding
Feb 1, 1983·Diseases of the Colon and Rectum·M T PheilsK Colquhoun
Jun 1, 1995·The Australian and New Zealand Journal of Surgery·J E Payne, H J Meyer
Feb 1, 1994·Annals of Surgery·D J BruinvelsC J van de Velde
Jul 1, 1993·Diseases of the Colon and Rectum·F SafiH G Beger
Jul 15, 1996·The Medical Journal of Australia·F A Macrae
Aug 1, 1996·The Australian and New Zealand Journal of Surgery·P H ChapuisI G Cunningham
Aug 1, 1996·The Australian and New Zealand Journal of Surgery·G A ThompsonP L Turner

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Citations

Jul 5, 2001·Journal of Clinical Epidemiology·R GijsenG A van den Bos
Jul 19, 2002·ANZ Journal of Surgery·James M Church
Oct 14, 2016·BMC Anesthesiology·C D DaleT Quasim
Aug 17, 2005·Digestive Surgery·José A AlvarezPaloma Alvarez
Jul 19, 2002·ANZ Journal of Surgery·Malcolm C A SteelFrank Chen

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