Indeterminate pleural metastasis on contrast-enhanced chest CT in non-small cell lung cancer: improved differential diagnosis with (18)F-FDG PET/CT

Annals of Nuclear Medicine
Min-Young JungHee-Seung Bom

Abstract

To evaluate the diagnostic performance of (18)F-fluorodeoxyglucose (FDG) PET/CT (PET/CT) for determining the presence of pleural metastasis in patients with indeterminate findings on a contrast-enhanced chest CT (CECT) for non-small cell lung cancer (NSCLC). This is a retrospective study. NSCLC patients (n = 63) who underwent thoracentesis and/or pleural biopsy were enrolled. CECT and PET/CT reports of pleural metastasis were analyzed based on comparison with cytological or histological confirmation. Negative cytologic results were re-confirmed with follow-up study prior to cancer-related therapy. CECT results were classified into 3 categories: negative, indeterminate, and positive for pleural metastasis. PET/CT results were classified into 2 categories (negative and positive for pleural metastasis) based on FDG uptake visual grading. The level of max SUV of pleura was also analyzed. ROC analysis was done for establishing the max SUV cut-off value. PET/CT could differentiate pleural metastasis with 70.8% diagnostic accuracy when the CECT finding was indeterminate (n = 24). Optimal cut-off value to predict pleural metastasis was 2.8 for max SUV. Diagnosis by max SUV 2.8 had lower sensitivity (86.3 vs. 92.2%), but higher specific...Continue Reading

References

Feb 15, 1991·Annals of Internal Medicine·R Menzies, M Charbonneau
Mar 1, 1990·AJR. American Journal of Roentgenology·A N LeungR R Miller
Dec 1, 1973·Archives of Internal Medicine·R W LightW C Ball
Feb 1, 1993·Radiology·N L Müller
Jul 1, 1997·Radiographics : a Review Publication of the Radiological Society of North America, Inc·J E Kuhlman
Feb 5, 1998·CA: a Cancer Journal for Clinicians·S H LandisP A Wingo
Jun 3, 1999·Diagnostic Cytopathology·H MotherbyA Böcking
Jul 17, 1999·Current Opinion in Pulmonary Medicine·R W Light
Apr 25, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A CarrettaP Zannini
May 5, 2000·European Radiology·J Arenas-JiménezM Lloret-Llorens
Jul 6, 2000·AJR. American Journal of Roentgenology·J J ErasmusE F Patz
Feb 16, 2002·The Annals of Thoracic Surgery·Noriyoshi SawabataUNKNOWN Japanese National Chest Hospital Study group for Lung Cancer
Nov 1, 2002·Radiology·Thomas F HanyGustav K von Schulthess
Apr 24, 2004·Radiology·Gottfried J SchafflerReingard M Aigner
Sep 1, 2004·The Annals of Thoracic Surgery·Robert James CerfolioAlfred A Bartolucci
Aug 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Anna C PfannenbergSusanne M Eschmann
May 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marine SoretIrène Buvat
Feb 24, 2009·AJR. American Journal of Roentgenology·Yigal AbramowitzNurith Hiller
Dec 2, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kazuhiro KitajimaKazuro Sugimura
Aug 10, 2011·International Journal of Oral and Maxillofacial Surgery·C A KrabbeJ G A M de Visscher

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Citations

Jul 26, 2013·AJR. American Journal of Roentgenology·Matthew KruseRathan M Subramaniam

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