Indexing the 'dark side of addiction': substance-induced affective symptoms and alcohol use disorders

Addiction
Cindy L EhlersKirk C Wilhelmsen

Abstract

The emergence of negative affective symptoms during the course of alcohol use disorders (AUDs) (e.g. 'dark side' symptoms) has been suggested theoretically; however, the description of their occurrence is limited. This study operationalized two negative affect symptoms and tested the strength of association between these phenotypes and (1) indicators of the clinical course of the severity of AUD, (2) comorbid Axis I psychiatric disorders, suicidal behaviors and trait neuroticism and (3) whether participants reported drinking to relieve the negative affective symptoms. A retrospective cross-sectional study was used to evaluate associations, using logistic regression, between the two negative affective symptoms and clinical measures of AUD severity and progression as well as comorbidity with other psychiatric disorders and conditions, adjusted for demographic characteristics. US community-based studies. A total of 2568 individuals with AUDs obtained from larger population studies that targeted individuals of European American (n = 1663), Mexican American and American Indian (n = 905) ancestry. Semi-Structured Assessment for the Genetics of Alcoholism was used to ascertain the two 'dark side' phenotypes, clinical diagnoses, the cl...Continue Reading

References

Mar 1, 1995·Journal of Studies on Alcohol·M A SchuckitJ Tipp
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
May 1, 1993·The American Journal of Psychiatry·M A SchuckitM Irwin
Jul 1, 1997·The American Journal of Psychiatry·M A SchuckitT L Smith
Feb 21, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A MarkouG F Koob
May 19, 1998·Journal of Psychopharmacology·C P O'BrienS J Robbins
Jan 1, 2000·Addiction·M HesselbrockV Hesselbrock
Dec 31, 2002·The American Journal of Psychiatry·Ulrich W PreussJohn R Kramer
Feb 6, 2004·Psychological Review·Timothy B BakerMichael C Fiore
Jul 2, 2004·The American Journal of Psychiatry·Cindy L EhlersDavid A Gilder
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Cassandra VietenKirk C Wilhelmsen
Jan 31, 2006·Alcoholism, Clinical and Experimental Research·Marc A SchuckitKenneth J Sher
Aug 3, 2007·The American Journal of Psychiatry·George Koob, Mary Jeanne Kreek
Oct 5, 2007·Current Psychiatry Reports·Rajita Sinha
Oct 26, 2007·Journal of Studies on Alcohol and Drugs·Marc A SchuckitVictor Hesselbrock
Jul 27, 2010·The American Journal on Addictions·Nelli BoykoffMark A Frye
Jul 6, 2014·Journal of Studies on Alcohol and Drugs·Kenneth R ConnerRebecca J Houston
Oct 14, 2014·Handbook of Clinical Neurology·Dongju Seo, Rajita Sinha
Jan 15, 2015·European Journal of Pharmacology·George F Koob
Sep 9, 2015·The American Journal on Addictions·Cindy L EhlersDavid A Gilder
Oct 31, 2015·Annual Review of Pharmacology and Toxicology·George F Koob, Barbara J Mason
Aug 1, 2016·The Lancet. Psychiatry·George F Koob, Nora D Volkow
Aug 17, 2017·JAMA Psychiatry·Allan M AndersenShizhong Han

❮ Previous
Next ❯

Citations

Dec 31, 2019·International Journal of Methods in Psychiatric Research·Cora von HammersteinAmandine Luquiens
Mar 13, 2020·The American Journal of Psychiatry·Alexis C EdwardsKenneth S Kendler
May 8, 2020·BJPsych Open·Martin Ø MyhreFredrik A Walby
Aug 23, 2020·Journal of Clinical Medicine·Adriana FarréFrancina Fonseca
Aug 4, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Esme Fuller-ThomsonSenyo Agbeyaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Alcohol Use Disorder

Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.