PMID: 64006Jan 1, 1976Paper

Indian childhood cirrhosis: genealogic data, alpha-foetoprotein, hepatitis antigen and circulating immune complexes

Transactions of the Royal Society of Tropical Medicine and Hygiene
R K Chandra

Abstract

Indian childhood cirrhosis is a significant cause of morbidity and mortality in young children in India. One hundred patients with ICC, 66 boys and 34 girls, were studied. Pedigree analysis yielded a segregation ratio of 0-2196, suggestive of an autosomal recessive inheritance. Serum alpha1-antitrypsin level was normal. Serum alpha-foetoprotein (AFP) concentration was increased in all the patients, parents and in some siblings. Serum immunoglobulins G, A, M, and D were elevated. Haemolytic complement and C3 were low. Electrophoretically altered complement components were detected in 36% of patients. There was an inverse relationship between C3 concentration and immunoconglutinin titre. Circulatingimmune complexes were detected in the sera of six out of ten patients who had significant proteinuria. Hepatitis B surface antigen (HBsAg) was present in the serum, ascitic fluid, saliva, urine and faeces of ICC patients more frequently than in controls. HBsAb was detected less often. Lymphocyte response to HBsAg was impaired. The first-degree relatives had a higher incidence of HBsAg and HBsAb than healthy controls. It is suggested that ICC occurs in infants with an inherited hepatocyte vulnerability and that one of the precipitating ...Continue Reading

References

Feb 1, 1975·The Journal of Experimental Medicine·R A Murgita, T B Tomasi
Jul 19, 1975·Lancet·N C NayakR Sachdeva
Jan 1, 1977·International Archives of Allergy and Applied Immunology·R K Chandra, R A Bhujwala
Mar 1, 1975·Archives of Disease in Childhood·R K Chandra
Jan 1, 1976·International Archives of Allergy and Applied Immunology·M von BlombergR J Scheper
Jan 30, 1971·Lancet·A ObayasiK Okochi
Jan 8, 1972·Lancet·N C NayakR K Chandra
Feb 1, 1973·Archives of Disease in Childhood·R K Chandra
Mar 1, 1972·Clinical Pediatrics·R K Chandra, V Seth
Apr 1, 1972·American Journal of Diseases of Children·R K ChandraG R Malik
Jan 1, 1969·Human Heredity·R K Chandra
Nov 1, 1960·The Journal of Pediatrics·S T ACHARS SRIRAMACHARI
Nov 1, 1960·The Journal of Pediatrics·D B JELLIFFE
Oct 1, 1964·Indian Journal of Pediatrics·A CHAUDHURI, K C CHAUDHURI

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Citations

May 1, 1982·Indian Journal of Pediatrics·S SahniR K Chandra
Apr 1, 1980·Gut·H J KlassT W Warnes
Nov 1, 1980·Indian Journal of Pediatrics·R K Chandra

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