PMID: 8950733Jan 1, 1996Paper

Indication and results of insulin therapy for gestational diabetes mellitus

Journal of Perinatal Medicine
H HoppW Besch

Abstract

The aim of this study was to determine whether amniotic fluid insulin concentration (AFI) is a better parameter than mean maternal blood glucose values (MBG) for deciding about insulin therapy in patients with gestational diabetes. MBG's were calculated on the base of 9 blood glucose levels during a 24 hour period after one week of diet therapy. In a prospective trial between 1987 and 1989 in Karlsburg, 123 gestational diabetic patients were randomized into two groups. Treatment was either based on the concentration of AFI or MBG levels. In a second series in Berlin, 103 patients were offered amniocentesis. 81 patients agreed and 22 refused. Treatment was then analogous to that in Karlsburg. In both groups of the randomized population, strict metabolic control was achieved. There was no difference regarding pregnancy complications. Earlier labor induction and higher cesarean section rates were seen in the non-invasive group (p < 0.05). The incidence of diabetic fetopathy and neonatal hypoglycemia was significantly lower in the invasive group (p < 0.01), even though the metabolic control parameters did not differ between the two groups. The results in Berlin correspond to these findings. In conclusion, AFI enables the recognitio...Continue Reading

References

Sep 1, 1989·American Journal of Obstetrics and Gynecology·O LangerM Divon
Jul 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·N FreinkelA Belton
Aug 1, 1973·American Journal of Obstetrics and Gynecology·J B O'SullivanR V Dandrow
Apr 1, 1994·American Journal of Obstetrics and Gynecology·O LangerF Arrendondo
Aug 1, 1954·Acta Endocrinologica·J PEDERSEN

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Citations

Jan 10, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·Derek TuffnellSteve Walkinshaw
Jun 16, 1999·American Journal of Obstetrics and Gynecology·M L SchwartzS L Lubarsky
Aug 13, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·R B Fraser, C Bruce
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Nisreen AlwanJane West
Nov 6, 2017·The Cochrane Database of Systematic Reviews·Julie BrownCaroline A Crowther

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