Indication criteria for liver transplantation for acute liver failure in Japan

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Satoshi Mochida

Abstract

In Japan, patients with hepatitis are diagnosed as having fulminant hepatitis and late-onset hepatic failure (LOHF) when grade II or more severe hepatic encephalopathy develops within 8 weeks and between 8 and 24 weeks, respectively, of the disease onset, with a prothrombin time of less than 40% of the standardized value. Fulminant hepatitis patients are classified into the acute and subacute types, in which the encephalopathy occurs within 10 days and later than 11 days, respectively. According to the nation-wide survey by the Intractable Liver Disease Study Group of Japan, liver transplantation was performed in 14% and 26% of the patients with the acute and subacute types, respectively, and in 19% with LOHF between 1998 and 2003. Survival rate of these patients was 77%, which was greater than those of the patients treated without liver transplantation; 54%, 24% and 12% in the acute and subacute types and LOHF, respectively. The indications for liver transplantation in fulminant hepatitis patients are currently determined according to the Guideline of the Acute Liver Failure Study Group of Japan in 1996, which is based on assessment of the prognosis of the patients at the onset of hepatic encephalopathy and reassessed 5 days l...Continue Reading

References

Jan 1, 1982·Acta Pathologica Japonica·K Abe, T Shikata
Dec 14, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shunichi SatoUNKNOWN Japanese National Study Group of Fulminant Hepatitis
Mar 11, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kenji FujiwaraUNKNOWN Intractable Liver Diseases Study Group of Japan

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Citations

Aug 9, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·UNKNOWN Organization Committee of 13th Asia-Pacific Congress of Clinical Microbiology and Infection
May 12, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Noriyo YamashikiNorihiro Kokudo
Oct 13, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuhiro MiyakeKazuhide Yamamoto
May 4, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomomi Kogiso, Katsutoshi Tokushige

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