Indication for surgery and the risk of postoperative nausea and vomiting after craniotomy: a case-control study

Journal of Neurosurgical Anesthesiology
Christine TanDonald E G Griesdale


The primary hypothesis of the study is that acoustic neuroma (AN) surgery and microvascular decompression (MVD) of cranial nerves increase the risk of postoperative nausea and vomiting (PONV). We designed a retrospective case-control study matched on age, sex, and year of surgery (≤2005 and >2005). Year of surgery was noted as a potential confounder, because routine antiemetic prophylaxis was strongly encouraged at the study site in 2005. Cases of PONV in the recovery room were matched to controls in a 1:2 manner using a perioperative database. Charts were then reviewed for the following data: American Society of Anesthesiologists grade, smoking status, craniotomy location, craniotomy indication, and type of anesthetic administered. The final analysis included 117 cases that were matched with 185 controls. Patients had a mean age of 50 years (SD=13), and 65% were female. Overall, the majority of craniotomies were supratentorial (70%) and performed for tumor resection (41%). On multivariable analysis, MVD [odds ratio (OR)=6.7; 95% confidence interval (CI), 2.0-22.7; P=0.002], AN (OR=3.3; 95% CI, 1.0-11.0; P=0.05), and epilepsy surgery (OR=2.8; 95% CI, 1.1-7.5; P=0.04) were associated with an increased likelihood of PONV when com...Continue Reading


Jan 1, 1994·Anaesthesia·R J Naylor, F C Inall
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Dec 28, 2002·Anesthesiology·Michaela StadlerJean G Boogaerts
Nov 20, 2003·Journal of Anesthesia·Samuel A IrefinZeyd Y Ebrahim
May 7, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hugo E CastagniniMichael H Nathanson
Jun 11, 2004·The New England Journal of Medicine·Christian C ApfelUNKNOWN IMPACT Investigators
Sep 7, 2004·British Journal of Anaesthesia·J R Sneyd
Apr 30, 2005·Journal of Palliative Medicine·D B GordonK Ford-Roberts
Nov 29, 2007·Anesthesia and Analgesia·Tong J GanUNKNOWN Society for Ambulatory Anesthesia
Dec 1, 2007·Epidemiology·Jan P VandenbrouckeUNKNOWN STROBE Initiative
Oct 30, 2010·Journal of Neurosurgery·Björn LatzKristin Engelhard

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