Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis.

Genes
Jacqueline KnaustChrista Kühn

Abstract

The premelanosome protein (PMEL) is important for fibril formation within melanosomes during vertebrate melanogenesis. Fibrils form a matrix for pigment deposition within pigmented tissues such as skin and hair. PMEL mutations are known to modulate eumelanic pigmentation in vertebrates. However, in bovines, PMEL mutations were also found to alter pheomelanic pigmentation resulting in coat color dilution. Furthermore, epistatic effects of a mutated PMEL allele were detected in the phenotypic expression of the bovine hair defect "rat-tail syndrome" (RTS) characterized by charcoal coat color and hair deformation. Reports about PMEL gene expression in non-pigmented tissues raised the hypothesis that there may be unknown functions of the PMEL protein beyond eumelanin deposition to PMEL fibrils. In our study, we analysed the PMEL protein expression in pigmented skin and non-pigmented bovine tissues (non-pigmented skin, thyroid gland, rumen, liver, kidney, and adrenal gland cortex). We found that a processed form of the bovine PMEL protein is expressed in pigmented as well as in non-pigmented tissues, which is in line with gene expression data from targeted RT-PCR and whole transcriptome RNAseq analysis. The PMEL protein is located in...Continue Reading

References

Oct 1, 1970·Developmental Biology·L L Theriault, L S Hurley
Jun 1, 1983·Brain Research Bulletin·H Barden, S Levine
Aug 15, 1995·European Journal of Biochemistry·P D Donatien, S J Orlow
Sep 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·H KlunglandS Lien
May 26, 1999·Journal of Animal Science·R R Schalles, L V Cundiff
Dec 14, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M Martínez-EsparzaJ C García-Borrón
Sep 16, 2005·Pigment Cell Research·Alexander C TheosMichael S Marks
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Leigh Anne ClarkKeith E Murphy
Oct 13, 2006·BMC Genetics·Emma BrunbergGabriella Lindgren
Feb 23, 2007·Nature·Jennifer Y Lin, David E Fisher
Sep 20, 2007·Nature Reviews. Molecular Cell Biology·Graça Raposo, Michael S Marks
Nov 14, 2007·PLoS Genetics·Bianca HaaseTosso Leeb
Feb 12, 2011·Pigment Cell & Melanoma Research·Lukas Sommer
Apr 25, 2012·Animal Genetics·Sheila M Schmutz, Dayna L Dreger
Jan 29, 2013·Pigment Cell & Melanoma Research·Brenda WattMichael S Marks
Feb 8, 2013·Molecular Biology of the Cell·Ralf M LeonhardtPeter Cresswell
Mar 26, 2014·Current Opinion in Cell Biology·Xufeng Wu, John A Hammer
Jul 30, 2014·Pigment Cell & Melanoma Research·Natsuko OkamotoEmi K Nishimura
Aug 12, 2014·Pigment Cell & Melanoma Research·Lorin WeinerJanice L Brissette
Jan 24, 2015·Science·Mathias UhlénFredrik Pontén
Apr 3, 2016·Genetics, Selection, Evolution : GSE·Jacqueline KnaustChrista Kuehn
Mar 9, 2017·Scientific Reports·Jia Shee HeeRalf M Leonhardt

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Datasets Mentioned

BETA
PRJEB3457

Methods Mentioned

BETA
FCS
glycosylations
glycosylation
RNAseq

Software Mentioned

Image Lab
CELL

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