Indication of retrograde tau spreading along Braak stages and functional connectivity pathways

European Journal of Nuclear Medicine and Molecular Imaging
Joseph Seemillerand the Alzheimer’s Disease Neuroimaging Initiative

Abstract

Tau pathology progression in Alzheimer's disease (AD) is explained through the network degeneration hypothesis and the neuropathological Braak stages; however, the compatibility of these models remains unclear. We utilized [18F]AV-1451 tau-PET scans of 39 subjects with AD and 39 sex-matched amyloid-negative healthy controls (HC) in the ADNI (Alzheimer's Disease Neuroimaging Initiative) dataset. The peak cluster of tau-tracer uptake was identified in each Braak stage of neuropathological tau deposition and used to create a seed-based functional connectivity network (FCN) using 198 HC subjects, to identify healthy networks unaffected by neurodegeneration. Voxel-wise tau deposition was both significantly higher inside relative to outside FCNs and correlated significantly and positively with levels of healthy functional connectivity. Within many isolated Braak stages and regions, the correlation between tau and intrinsic functional connectivity was significantly stronger than it was across the whole brain. In this way, each peak cluster of tau was related to multiple Braak stages traditionally associated with both earlier and later stages of disease. We show specificity of healthy FCN topography for AD-pathological tau as well as p...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·Heiko Braak, E Braak
Mar 8, 1984·The New England Journal of Medicine·S B Prusiner
Oct 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·P VermerschA Delacourte
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Aug 20, 2005·Brain Research. Developmental Brain Research·Wencheng YangMichael J Strong
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerMark S Mintun
Aug 15, 2006·NeuroImage·Jörn Diedrichsen
Dec 26, 2006·Annals of Neurology·William W SeeleyStephen J Dearmond
Feb 28, 2008·Journal of Magnetic Resonance Imaging : JMRI·Clifford R JackMichael Weiner
Nov 8, 2008·Current Opinion in Neurology·William W Seeley
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerKeith A Johnson
Apr 3, 2009·Journal of Neurophysiology·Michael D FoxMarcus E Raichle
Apr 21, 2009·Neuron·William W SeeleyMichael D Greicius
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bharat B BiswalMichael P Milham
Jun 26, 2010·Frontiers in Systems Neuroscience·Yan Chao-Gan, Zang Yu-Feng
Sep 10, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hans ZempelEva-Maria Mandelkow
Apr 26, 2011·Acta Neuropathologica·Heiko Braak, Kelly Del Tredici
Jul 19, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Victor L VillemagneChristopher C Rowe
Sep 6, 2011·NeuroImage·Xiaoqian J ChaiSusan Whitfield-Gabrieli
Mar 27, 2012·Neuron·Ashish RajMichael Weiner
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michiyo IbaVirginia M-Y Lee
Aug 21, 2013·Journal of Alzheimer's Disease : JAD·David T ChienHartmuth C Kolb
Sep 3, 2013·NeuroImage·Jonathan D PowerSteven E Petersen
Apr 4, 2015·PloS One·Birk Diedenhofen, Jochen Musch
Nov 21, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Masoud TahmasianChristian Sorg
Mar 5, 2016·Neuron·Michael SchöllWilliam J Jagust
Mar 11, 2016·Brain : a Journal of Neurology·Rik OssenkoppeleGil D Rabinovici
Jun 21, 2016·Annals of Neurology·Hanna ChoChul Hyoung Lyoo
Jan 1, 2017·NeuroImage·Gabriel Gonzalez-EscamillaAlzheimer's Disease Neuroimaging Initiative
Apr 11, 2017·Alzheimer Disease and Associated Disorders·Gregory S DayJohn C Morris
Jun 4, 2017·Neurobiology of Aging·Merle Christine HoenigAlexander Drzezga
Nov 6, 2017·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·David T JonesClifford R Jack
Nov 11, 2017·Data in Brief·Suzanne L BakerWilliam J Jagust
Jan 3, 2018·Brain : a Journal of Neurology·Thomas E CopeJames B Rowe
Jan 10, 2018·Brain : a Journal of Neurology·Merle Christine HoenigAlexander Drzezga
Oct 29, 2018·Human Brain Mapping·Jacob W VogelSwedish BioFinder Study
Feb 17, 2019·Brain : a Journal of Neurology·Nicolai FranzmeierAlzheimer’s Disease Neuroimaging Initiative
Nov 2, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Rik OssenkoppeleOskar Hansson
May 28, 2020·Nature Communications·Jacob W VogelSwedish BioFinder Study
Nov 29, 2020·Science Advances·Nicolai FranzmeierMichael Ewers

Related Concepts

Alzheimer's Disease
Brain
Nerve Degeneration
Tau Proteins
Disease Progression
Uptake
Initiative
Downstream
Biological Neural Networks
Neuroimaging

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