Indication to pelvic lymph nodes dissection for prostate cancer: the role of multiparametric magnetic resonance imaging when the risk of lymph nodes invasion according to Briganti updated nomogram is <5

Prostate Cancer and Prostatic Diseases
Francesco PorpigliaStefano De Luca

Abstract

The Briganti updated nomogram (BN) is the most popular predictive model aiming to predict the presence of lymph node invasion (LNI) in patients with prostate cancer (PCa), but it lacks information obtained by preoperative imaging. The primary aim of the study was to evaluate the role of multiparametric prostate magnetic resonance imaging (mp-MRI) in the indication to perform pelvic lymph nodes dissection (PLND) or not in patients with risk of LNI according to BN below 5%. Since March 2012 and September 2016, 310 patients who underwent a preoperative mp-MRI for staging purpose and subsequent robot-assisted extended PLND (RAEPLND) were retrospectively evaluated. Mp-MRIs were prospectively analyzed by two experienced radiologists. The imaging parameters analyzed were the presence of extracapsular extension (ECE), seminal vesicles invasion (SVI) and predominant Gleason pattern 4 (pG4). All patients underwent RAEPLND by two experienced surgeons with a standardized technique. A dedicated uropathologist performed all pathological analysis. Univariate analysis and multivariate logistic regression analysis were used in order to identify the predictors of LNI in patients with PCa. In the overall population, 57 (18.4%) patients had histol...Continue Reading

References

May 16, 2002·Seminars in Urologic Oncology·Misop Han, Alan W Partin
May 19, 2007·The Journal of Urology·Ian ThompsonUNKNOWN AUA Prostate Cancer Clinical Guideline Update Panel
Mar 4, 2011·European Urology·Alessandro SciarraJ Alfred Witjes
Mar 12, 2011·Current Urology Reports·K A Keegan, M S Cookson
Apr 15, 2011·BJU International·Marcelo A OrvietoVipul R Patel
Feb 11, 2012·European Radiology·Jelle O BarentszUNKNOWN European Society of Urogenital Radiology
Nov 12, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
May 1, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Francesco PorpigliaDaniele Regge
Dec 24, 2015·World Journal of Urology·Alessandro ContiRodolfo Montironi

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Citations

Aug 23, 2019·Integrated Environmental Assessment and Management·Antonio Franco, Roger van Egmond
Mar 22, 2019·Cancer Research·Inês SantiagoNoam Shemesh
Apr 4, 2021·Journal of Clinical Medicine·Alessandro MorlaccoGiacomo Novara

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Methods Mentioned

BETA
dissection
biopsy

Software Mentioned

PIRADS
Functool

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