PMID: 7518589May 1, 1994Paper

Indications and limitations of class II and III antiarrhythmic drugs in atrial fibrillation

Pacing and Clinical Electrophysiology : PACE
S H Hohnloser

Abstract

In summary, the Class III antiarrhythmic agents amiodarone and sotalol are effective in restoring sinus rhythm in patients with chronic atrial fibrillation with a higher effectiveness of amiodarone. Both agents successfully prevent recurrent episodes of atrial fibrillation after electrical cardioversion and both can control heart rate in persistent atrial fibrillation. Amiodarone appears to be particularly suitable in patients with atrial fibrillation and concomitant congestive heart failure because it lacks clinically relevant negative inotropic activity. Both substances are also effective in controlling ventricular arrhythmias that are frequently present in patients with atrial fibrillation. Finally, both drugs possess antiadrenergic activity, which makes the substances particularly attractive in patients with coronary heart disease as the underlying cause of atrial fibrillation.

References

Dec 1, 1976·The American Journal of Cardiology·M B RosenbaumM V Elizari
Jun 15, 1991·The American Journal of Cardiology·S H HohnloserH Just
Apr 15, 1989·The American Journal of Cardiology·E V PlatiaG Das
Aug 1, 1987·Journal of the American College of Cardiology·J E AtwoodV F Froelicher
Jan 1, 1986·The American Journal of Cardiology·R L GoldJ S Alpert
Dec 1, 1985·Journal of the American College of Cardiology·L N HorowitzH R Kay
Oct 1, 1983·American Heart Journal·T B GraboysB Lown
Nov 26, 1993·The American Journal of Cardiology·H R MiddlekauffW G Stevenson

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Citations

Nov 1, 1996·Cardiology Clinics·F Jung, J P DiMarco
Aug 5, 2000·Clinics in Geriatric Medicine·R Lampert, M D Ezekowitz
Jun 1, 1997·Journal of Cardiovascular Electrophysiology·A HeiselH Pitschner
Feb 25, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·S H HohnloserG Grönefeld
Mar 1, 1996·Pacing and Clinical Electrophysiology : PACE·M Brignole, C Menozzi
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·Y G Li, S H Hohnloser

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