Indications and outcomes of keratoplasties in children during a 40-year period

Acta Ophthalmologica
Anna S MajanderKari Krootila


To report the indications and the outcomes of keratoplasties in children over four decades. A retrospective cohort study of patients aged 16 years or younger who underwent keratoplasty in the Helsinki University Eye Hospital during 1968-2011. Diagnosis, preoperative status, age at the time of surgery, surgical technique, complications and follow-up time were registered. Main outcome measures were visual acuity and graft survival as assessed by Kaplan-Meier analysis. The independent role of risk factors on outcomes was evaluated by Cox multivariate regression analysis. Forty-eight keratoplasties, 42 penetrating and six lamellar, were performed in 44 eyes of 39 children at the age of 4.5 months to 16 years (median, 12 years). Five patients had bilateral grafts, and five grafts were regrafts. The indication for keratoplasty was injury for 13 grafts, non-traumatic acquired corneal opacities for 11, keratoconus for eight, corneal dystrophy for seven, congenital corneal opacities for six and aniridia for three grafts. The cumulative proportion of clear grafts was 46% at 5 years postoperatively, and the median follow-up time of clear grafts was 5.1 years (range, 0.4-29 years) for 41 penetrating allografts (PKP). Simultaneous intraocul...Continue Reading


Oct 1, 1984·Ophthalmology·R D StultingJ A Gammon
Aug 1, 1997·The British Journal of Ophthalmology·A VailW J Armitage
Sep 26, 2003·The British Journal of Ophthalmology·K McClellanF Billson
Feb 24, 2005·Journal of Pediatric Ophthalmology and Strabismus·Adi MichaeliD S Rootman
Mar 19, 2005·The British Journal of Ophthalmology·H Y PatelC N J McGhee
Feb 20, 2007·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Ali Al-GhamdiMichael D Wagoner
Jun 19, 2007·Survey of Ophthalmology·Anita PandaSatya Priya
Jul 3, 2007·American Journal of Ophthalmology·Gerald W ZaidmanCatherine C Furey
Aug 2, 2007·Cornea·Namrata SharmaRasik B Vajpayee
Jul 25, 2008·Cornea·Kavita V RaoVirender S Sangwan
Sep 4, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C LangeM Bach
Mar 21, 2009·Survey of Ophthalmology·M VanathiTanuj Dada
Sep 3, 2009·Cornea·Charles HuangMark J Mannis
Apr 20, 2010·Clinical & Experimental Ophthalmology·Harminder S DuaDalia G Said
Oct 12, 2010·Ophthalmology·Marie T LoweKeryn A Williams
Mar 29, 2011·Transplantation Proceedings·R LimaiemL El Matri
Sep 11, 2012·Ophthalmology·Anna S MajanderKari Krootila
Jul 25, 2013·Acta Ophthalmologica·Maria HovlykkeKim Nielsen
Oct 10, 2013·American Journal of Medical Genetics. Part a·Anuradha GaneshAlex V Levin
Apr 3, 2015·Acta Ophthalmologica·Pekka RuusuvaaraKirsi Setälä


Nov 13, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S J LangT Reinhard
Feb 13, 2021·American Journal of Ophthalmology·Denise WajnsztajnNational Health Service Blood and Transplant Ocular Tissue Advisory Group and contributing ophthalmologists (OTAG Study 29)

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.