Indications for treatment of sarcoidosis

Current Opinion in Pulmonary Medicine
Hilario NunesDominique Valeyre

Abstract

To describe the current knowledge on indications for sarcoidosis treatment. Despite the lack of evidence-based recommendations, the sarcoidosis community has adopted the concept of starting systemic anti-inflammatory treatment because of potential danger (risk of severe dysfunction on major organs or death) or unacceptable impaired quality of life (QoL). On the contrary, while QoL and functionality are patients' priorities, few studies have evaluated treatment effect on patient-reported outcomes. The awareness of long-term corticosteroids toxicities and consequences on QoL and the emergence of novel drugs have changed therapeutic management. Second-line therapy, mainly methotrexate and azathioprine, are indicated for corticosteroids sparing or corticosteroids-resistant sarcoidosis. TNF-α inhibitors are a useful third-line therapy in chronic refractory disease. In addition to organ-targeted treatment, efforts should also be taken for treating nonorgan-specific symptoms, such as physical training for fatigue, and various disease complications. Clinicians should offer a tailored treatment for each patient and ensure a holistic multidisciplinary approach, including pharmacological and nonpharmacological interventions. Patient-cente...Continue Reading

References

Apr 24, 1995·Archives of Internal Medicine·E E Lower, R P Baughman
May 1, 1997·American Journal of Respiratory and Critical Care Medicine·P ZabelM Schlaak
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·M BaltzanM G Cosio
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·R P BaughmanUNKNOWN Case Control Etiologic Study of Sarcoidosis (ACCESS) research group
Jan 18, 2002·Chest·Anne PietinalhoUNKNOWN Finnish Pulmonary Sarcoidosis Study Group
Jul 13, 2002·Chest·Robert P BaughmanElyse E Lower
Aug 13, 2002·Current Opinion in Pulmonary Medicine·Violeta Mihailovic Vucinic
May 10, 2003·American Journal of Respiratory and Critical Care Medicine·Christopher E CoxMarc A Judson
Jun 18, 2003·European Radiology·Marjolein DrentJohny A Verschakelen
Mar 10, 2004·Chest·Christopher E CoxMarc A Judson
Apr 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ali A HaydarDavid J A Goldsmith
Apr 6, 2006·QJM : Monthly Journal of the Association of Physicians·R P BaughmanB Thompson
Jul 15, 2006·American Journal of Respiratory and Critical Care Medicine·Robert P BaughmanUNKNOWN Sarcoidosis Investigators
Feb 8, 2008·The European Respiratory Journal·M A JudsonUNKNOWN Centocor T48 Sarcoidosis Investigators
Feb 11, 2009·Journal of Computer Assisted Tomography·Jean-Marc NaccachePierre Yves Brillet
Jan 22, 2010·Respiratory Medicine·Amanda C SchuttMarc A Judson
Jul 10, 2010·Lung India : Official Organ of Indian Chest Society·Rajiv Paliwal
Apr 22, 2011·Clinical and Vaccine Immunology : CVI·Matthew J LozaRobert P Baughman
May 14, 2011·The European Respiratory Journal·D H SahooD A Culver
Oct 19, 2011·Archives of Dermatology·Robert P BaughmanElyse E Lower
Nov 15, 2011·The European Respiratory Journal·A NardiH Nunes
Nov 29, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·R J ErckensM Drent
Dec 14, 2011·Expert Review of Clinical Immunology·Robert P Baughman, Hilario Nunes
Aug 25, 2012·Journal of Pain and Symptom Management·Elyse E LowerRobert P Baughman
Oct 12, 2012·Clinical Ophthalmology·Elyse E LowerAdam H Kaufman
Jan 2, 2013·Journal of the American Academy of Dermatology·Robert J PariserMolly Smith
Feb 12, 2013·The European Respiratory Journal·Robert P BaughmanElyse E Lower
Mar 30, 2013·Chest·Adriane D M VorselaarsJan C Grutters
Oct 5, 2013·Lancet·Dominique ValeyreJoachim Müller-Quernheim
Nov 12, 2013·Respiratory Medicine·Robert P Baughman, Elyse E Lower
Feb 4, 2014·The European Respiratory Journal·Nadera J SweissRobert P Baughman
Feb 8, 2014·The Lancet. Respiratory Medicine·Simon Lf WalshDavid M Hansell
Feb 22, 2014·The European Respiratory Journal·Petal A WijnenMarjolein Drent
Mar 25, 2014·Arthritis Research & Therapy·Nathalie Saidenberg-Kermanac'hMarie-Christophe Boissier
Mar 29, 2014·Lung India : Official Organ of Indian Chest Society·Beuy Joob, Viroj Wiwantikit
Jul 19, 2014·The European Respiratory Journal·Marc A JudsonElliot S Barnathan
Oct 11, 2014·Respiratory Medicine·Nabeel HamzehLisa A Maier
Jan 17, 2015·American Journal of Respiratory and Critical Care Medicine·Marc A JudsonDavid E Victorson

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Citations

Jul 24, 2020·Current Opinion in Pulmonary Medicine·Jacobo SellarésRobert P Baughman
Feb 7, 2020·Journal of Clinical Medicine·Catharina C MoorMarlies S Wijsenbeek
Mar 4, 2020·Trends in Immunology·Yves PachecoAlain Calender
Jul 24, 2021·Advances in Therapy·Dominique ValeyreJean-François Bernaudin

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