PMID: 18203885Jan 22, 2008Paper

Indicator amino acid oxidation: concept and application

The Journal of Nutrition
Rajavel ElangoP B Pencharz

Abstract

The indicator amino acid oxidation (IAAO) method is based on the concept that when 1 indispensable amino acid (IDAA) is deficient for protein synthesis, then all other IDAA, including the indicator amino acid, will be oxidized. With increasing intakes of the limiting amino acid, IAAO will decrease, reflecting increasing incorporation into protein. Once the requirement for the limiting amino acid is met, there will be no further change in the indicator oxidation. Originally, the IAAO method was designed to determine amino acid requirements in growing pigs. The minimally invasive IAAO method developed in humans has been systematically applied to determine IDAA requirements in adults. Due to its noninvasive nature, the IAAO method has also been used to determine requirements for amino acids in neonates and children, and in disease. The IAAO model has recently been applied to determine the metabolic availability (MA) of amino acids from dietary proteins and to determine total protein requirements. The IAAO method is robust, rapid, and reliable; it has been used to determine amino acid requirements in different species, across the life cycle, and in diseased populations. The recent application of IAAO to determine MA of amino acids ...Continue Reading

References

May 1, 1986·The British Journal of Nutrition·R O Ball, H S Bayley
Sep 1, 1983·The British Journal of Nutrition·K I KimH S Bayley
Sep 1, 1983·The British Journal of Nutrition·K I Kim, H S Bayley
Jul 1, 1993·The Journal of Nutrition·L J WykesP B Pencharz
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·J A BruntonP B Pencharz
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·R BrossP B Pencharz
Nov 8, 2002·The Journal of Nutrition·Wantanee KriengsinyosPaul B Pencharz
Nov 9, 2002·American Journal of Physiology. Endocrinology and Metabolism·Glenda Courtney-MartinPaul B Pencharz
Mar 11, 2003·Annual Review of Nutrition·Paul B Pencharz, Ronald O Ball
May 6, 2003·The Journal of Nutrition·Anna K ShovellerRonald O Ball
Dec 21, 2005·The Journal of Nutrition·Diana R MagerPaul B Pencharz
Mar 9, 2006·The American Journal of Clinical Nutrition·Justine M TurnerPaul B Pencharz
Apr 28, 2006·Pediatric Research·Diana R MagerPaul B Pencharz
Nov 10, 2006·The American Journal of Clinical Nutrition·Mohammad A HumayunPaul B Pencharz
Aug 9, 2007·The American Journal of Clinical Nutrition·Rajavel ElangoPaul B Pencharz
Oct 9, 2007·The American Journal of Clinical Nutrition·Mohammad A HumayunPaul B Pencharz
Dec 20, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Rajavel ElangoPaul B Pencharz

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Citations

May 15, 2010·European Journal of Clinical Nutrition·P B Pencharz
Nov 4, 2011·The American Journal of Clinical Nutrition·Lisha HuangJohannes B van Goudoever
Oct 31, 2012·The British Journal of Nutrition·Raja R Pillai, Anura V Kurpad
Nov 29, 2017·International Journal of Sport Nutrition and Exercise Metabolism·Amy J Hector, Stuart M Phillips
Nov 6, 2018·Medicine and Science in Sports and Exercise·Julia M MalowanyDaniel R Moore
May 15, 2019·Medicine and Science in Sports and Exercise·Jenna B GillenDaniel R Moore
Nov 24, 2019·The American Journal of Clinical Nutrition·Madeleine A EnnisRajavel Elango
Feb 27, 2020·The British Journal of Nutrition·Matthew HarrisonDavid Allaway
Aug 8, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Patrycja Puiman, Barbara Stoll
Oct 21, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Rajavel ElangoPaul B Pencharz
Nov 4, 2011·The American Journal of Clinical Nutrition·Rajavel ElangoPaul B Pencharz
Jan 16, 2014·European Journal of Clinical Nutrition·P PencharzR Weisell
May 6, 2015·Journal of Animal Science and Biotechnology·Jaap van Milgen, Jean-Yves Dourmad
Jul 23, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Emily Arentson-LantzRajavel Elango
May 1, 2015·The American Journal of Clinical Nutrition·Donald K LaymanTeresa A Davis
Aug 17, 2016·Nutrients·Glenda Courtney-MartinRajavel Elango
Jan 10, 2018·Frontiers in Nutrition·Jeffrey E PackerDaniel R Moore
Oct 31, 2008·The British Journal of Nutrition·Sofia Morais, Luís E C Conceição
Jan 17, 2014·The American Journal of Clinical Nutrition·Minghua TangWayne W Campbell
Apr 26, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Paul B PencharzRobert R Wolfe
May 1, 2015·The American Journal of Clinical Nutrition·Jacomine E Hogewind-SchoonenboomJohannes B van Goudoever
Apr 7, 2015·Journal of Pediatric Gastroenterology and Nutrition·Jacomine E Hogewind-SchoonenboomJohannes B van Goudoever
Apr 8, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jorge A Coss-BuRyan T Hurt
Sep 19, 2019·The Journal of Nutrition·Paul J Moughan, Robert R Wolfe
Oct 31, 2012·The British Journal of Nutrition·Rajavel ElangoPaul B Pencharz
Jan 20, 2012·The Journal of Nutrition·Kristine L UrschelPat A Harris
Oct 31, 2012·The British Journal of Nutrition·Rajavel ElangoPaul B Pencharz
Jan 23, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Adam J KuchniaCarrie P Earthman

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