Indicators of anxiety and depression in women with the fragile X premutation: assessment of a clinical sample

Journal of Intellectual Disability Research : JIDR
Ave M LachiewiczAllyn McConkie-Rosell

Abstract

Current research suggests that depression and anxiety may be common problems in women with the fragile X (FMR1) premutation. To learn more about this in a clinical setting, we asked 33 women with the FMR1 premutation and 20 women without the FMR1 premutation to complete the Brief Carroll Depression Scale (Brief CDS) and the Multidimensional Anxiety Questionnaire (MAQ) and to provide information about mental health medication use. Questionnaire findings were compared between groups and with normative samples. Trinucleotide (CGG) repeat counts were also correlated to checklist findings. Both women with the FMR1 premutation and the comparison group had high current mental health medication use (33% vs. 35%). Approximately 1/3 of the women from both groups had high Brief CDS Total T-scores (33% vs. 30%). More women with the FMR1 premutation had at least one elevated MAQ Total or sub-scale T-score than the comparison group (39% vs. 10%, P = 0.03). Twenty-one per cent of women with the FMR1 premutation had all three of the indicators of distress targeted in this study vs. none of the women in the comparison samples (P < 0.05). There was no statistically significant correlation between CGG repeat size and abnormal checklist findings u...Continue Reading

References

Jul 15, 1994·American Journal of Medical Genetics·A M Lachiewicz, D V Dawson
Jul 15, 1994·American Journal of Medical Genetics·D Z LoeschJ Mulley
Feb 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·W E SobeskyR J Hagerman
Oct 1, 1993·Journal of Developmental and Behavioral Pediatrics : JDBP·M M MazzoccoR J Hagerman
Aug 9, 1996·American Journal of Medical Genetics·P FrankeU Froster
Sep 27, 1996·Psychiatry Research·N M ThompsonC Johnson
Aug 1, 1997·Journal of Autism and Developmental Disorders·M M MazzoccoA L Reiss
Jun 2, 1998·American Journal of Mental Retardation : AJMR·J E RiddleR J Hagerman
Apr 5, 2000·American Journal of Medical Genetics·F TassoneP J Hagerman
Apr 17, 2001·Depression and Anxiety·D L Dunner
Sep 8, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·D C CrawfordS L Sherman
Dec 18, 2001·American Journal of Medical Genetics·C JohnstonA Reiss
Jun 6, 2003·Journal of Intellectual Disability Research : JIDR·L A Ricci, R M Hodapp
Aug 5, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Monica AzizMike Patton
Aug 14, 2003·Journal of Developmental and Behavioral Pediatrics : JDBP·Cindy JohnstonAllan L Reiss
Mar 31, 2004·American Journal of Human Genetics·Paul J Hagerman, Randi J Hagerman
Apr 10, 2004·American Journal of Mental Retardation : AJMR·Leonard AbbedutoMelissa M Murphy
Dec 21, 2004·Human Reproduction·A K SullivanS L Sherman
Jun 9, 2005·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Aug 11, 2005·Science in China. Series C, Life Sciences·Saskia VuurensScott Salzman
Sep 27, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·David HesslRandi J Hagerman
May 12, 2007·Journal of Intellectual Disability Research : JIDR·Anne WheelerDon Bailey
Feb 13, 2008·American Journal of Medical Genetics. Part a·Donald B BaileyDeborah Hatton
Jun 17, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jane E RobertsRobert N Golden

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Citations

Jul 17, 2012·Journal of Genetic Counseling·Brenda FinucaneAllyn McConkie-Rosell
Oct 13, 2011·Genetic Testing and Molecular Biomarkers·Tri Indah WinarniFlora Tassone
Aug 6, 2013·Intellectual and Developmental Disabilities·Brenda FinucaneElliott W Simon
Jan 24, 2014·American Journal on Intellectual and Developmental Disabilities·Nicole M Russo-PonsaranElizabeth Berry-Kravis
Jan 24, 2014·American Journal on Intellectual and Developmental Disabilities·Melissa RaspaEllen Bishop
Aug 20, 2014·Journal of Neurodevelopmental Disorders·Jim GrigsbyJin-Chen Yang
Oct 30, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Claudine M KraanKim M Cornish
May 17, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Bridgette L TonnsenJane E Roberts
Sep 5, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Heather A KennaNatalie L Rasgon
Jan 29, 2013·Neuroscience and Biobehavioral Reviews·Claudine M KraanKim M Cornish

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