PMID: 8599296Jan 1, 1995Paper

Indicators of histohypoxia

Acta Anaesthesiologica Scandinavica. Supplementum
N Willis, J Mogridge

Abstract

Cellular tissue damage due to inadequate oxygen supply is frequently encountered in the critically ill patient and can be the end result of a number of conditions. The eventual disruption to the normal processes required for the cell to survive can be due either to the hypoxic state per se or by damage caused during reperfusion of the tissue. Blood gas analysis is commonly used as a macro indicator of oxygen supply, state of art blood gas analysers provide information for oxygen tension (pO2), haemoglobin oxygen saturation (SO2) and concentration (THb), ideally, in arterial and mixed venous blood. The concurrent measurement of carbon dioxide tension (pCO2) and pH will allow the calculation of variables which assist in differentiating between respiratory and non-respiratory conditions. Measurement of cardiac output and clinical assessment of the patients' oxygen requirements will complete the macro picture of supply and demand and although computed indicators of hypoxia have been improved in recent years (1, 2) the definitive diagnosis of histohypoxia requires the measurement of the cellular and subcellular products of metabolic processes that are present when an inappropriate concentration of oxygen has been experienced. Howeve...Continue Reading

Citations

Mar 12, 2003·Resuscitation·Stephan KlausLudger Bahlmann
Mar 31, 2005·Annals of Surgery·Lars Tue SørensenTorben Jørgensen
Oct 19, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·R GuptaN J Shaw
Jul 13, 2000·The Annals of Thoracic Surgery·J S TweddellS B Litwin

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