Indicators of induced subacute ruminal acidosis (SARA) in Danish Holstein cows

Acta Veterinaria Scandinavica
A M DanscherJ C Plaizier


The prevalence of subacute ruminal acidosis (SARA) in dairy cows is high with large impact on economy and welfare. Its current field diagnosis is based on point ruminal pH measurements by oral probe or rumenocentesis. These techniques are invasive and inaccurate, and better markers for the diagnosis of SARA are needed. The goal of this study was to evaluate clinical signs of SARA and to investigate the use of blood, faecal and urinary parameters as indicators of SARA. Six lactating, rumen cannulated, Danish Holstein cows were used in a cross-over study with three periods. The first and second periods included two cows on control diet and two cows on nutritional SARA challenge. The third period only included two cows on SARA challenge. Control diet was a conventional total mixed ration [45.5% dry matter (DM), 17.8% crude protein, 43.8% neutral detergent fibre, and 22.5% acid detergent fibre (DM basis)]. SARA challenge was conducted by substituting control diet with grain pellets (50% wheat/barley) over 3 days to reach 40% grain in the diet. Ruminal pH was measured continuously. Blood samples were collected once daily at 7 h after feeding. Samples of faeces and urine were collected at feeding, and at 7 and 12 h after feeding. Blo...Continue Reading


Apr 1, 1993·Journal of Dairy Science·R L Ireland-Perry, C C Stallings
Feb 17, 1998·Journal of Animal Science·T G Nagaraja, M M Chengappa
Dec 22, 2004·Veterinary Research Communications·J M D EnemarkN B Kristensen
Mar 11, 2008·The Veterinary Journal·Luke O'GradyFinbar J Mulligan
Jan 24, 2009·Journal of Dairy Science·A M DanscherM B Thoefner
Jun 2, 2009·The Veterinary Record·J L KleenJ P T M Noordhuizen
Oct 19, 2010·Veterinary Medicine International·Matteo GianesellaElisabetta Giudice


Aug 27, 2016·Journal of Animal Physiology and Animal Nutrition·B StefanskaJ Skomiał
Mar 17, 2017·Journal of Animal Physiology and Animal Nutrition·M EgerGerhard Breves
Dec 17, 2018·Animal Science Journal = Nihon Chikusan Gakkaihō·Keiko NishimuraShiro Kushibiki
Jul 18, 2019·Animal : an International Journal of Animal Bioscience·C VillotM Silberberg
Mar 3, 2020·The Journal of Dairy Research·Maya ZachutLorenzo E Hernández-Castellano
Nov 19, 2019·Oxidative Medicine and Cellular Longevity·Dan LuoKehui Ouyang
Mar 8, 2020·Animals : an Open Access Journal From MDPI·Rejane Santos SousaEnrico Lippi Ortolani
Jul 1, 2020·Journal of Animal Physiology and Animal Nutrition·Theresa OrtonMelanie Brede
Aug 28, 2020·Frontiers in Veterinary Science·Chenxu ZhaoGuowen Liu
Dec 12, 2018·Journal of Cellular Physiology·Chenxu ZhaoGuowen Liu
Dec 9, 2017·Journal of Animal Physiology and Animal Nutrition·E HumerQ Zebeli
Nov 11, 2019·Journal of Dairy Science·A MenschingA R Sharifi
Aug 25, 2018·Animal : an International Journal of Animal Bioscience·J C PlaizierQ Zebeli
Feb 21, 2020·Sensors·Ramūnas AntanaitisMindaugas Televičius
Oct 18, 2020·Scientific Reports·Gary A AtkinsonAlison H Kingston-Smith
Dec 31, 2020·Animals : an Open Access Journal From MDPI·Natalia Sato MinamiEnrico Lippi Ortolani

Related Concepts

Metabolic Acidosis
Bos indicus
Cattle Diseases
Stomach Diseases
Viral Markers
Cross-Over Studies

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.