Indicators of kidney damage in patients with multiple myeloma in the process of chemotherapeutic treatment

Klinicheskaia laboratornaia diagnostika
I A GoroshinskayaA V Shulga

Abstract

The purpose was to study the level of acute kidney injury markers cystatin C, KIM-1, IL-18, NGAL and L-FABR in the blood and urine of patients with the initially identified secreting multiple myeloma (MM) before and during chemotherapeutic treatment. The content of renal markers was examined by ELISA using commercial kits. The study included 23 patients with MM who received 6-8 21-day cycles of chemotherapy (CT) according to the VCD scheme. The results were compared in the main group of 13 patients who had a selective plasma exchange a day before each of the cycles of HT with the use of the Evaclio plasma separator and in a control group of 10 patients treated without extracorporeal detoxification. MM patients before treatment showed an increase in blood IL-18 level of 8.6 times, KIM-1 - 3.1 times, L-FABR - 57.4%, cystatin C - 48.4% and also a decrease in the level of NGAL in 75% of patients by 74.3% compared to the level in healthy, while in the urine initially increased only KIM-1 content by 2.4 times and NGAL by 2.6 times. Conducting multi-course chemotherapy with previous plasma exchange had a more lenient effect on MM patients, as evidenced by a lower KIM-1 level in blood and urine after 1 and 2 courses of HT, as well as I...Continue Reading

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