Indinavir-associated interstitial nephritis and urothelial inflammation: clinical and cytologic findings

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jeffrey B. KoppKirk D Miller

Abstract

The objective of the present study was to characterize the genitourinary syndromes that accompany indinavir-associated pyuria. Of 23 indinavir-treated patients with persistent pyuria, 4 had isolated interstitial nephritis, 10 had both interstitial nephritis and urothelial inflammation, 7 had isolated urothelial inflammation, and 2 had pyuria with nonspecific urinary tract inflammation. A total of 21 patients had multinucleated histiocytes identified by cytologic testing of urine specimens. Urine abnormalities resolved in all 20 patients who stopped receiving indinavir therapy. Pyuria continued in the 3 patients who continued receiving indinavir. Six patients had elevated serum creatinine levels, which returned to baseline levels when indinavir was discontinued. In conclusion, indinavir-associated pyuria was frequently associated with evidence of interstitial nephritis and/or urothelial inflammation, multinucleated histiocytes were commonly present in urine specimens, and cessation of indinavir therapy was associated with prompt resolution of urine abnormalities.

References

Jan 9, 1997·The New England Journal of Medicine·S ChughE A Alexander
Jan 9, 1997·The New England Journal of Medicine·K T TashimaS Rosen
Jul 15, 1997·Annals of Internal Medicine·J B KoppJ Falloon
Oct 27, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J S BernsJ Turner
Oct 24, 1997·Urology·D L GentleA F Wood
Oct 24, 1997·Urology·R G BruceP W Rutter
Apr 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F MartinezC Katlama
May 23, 1998·The Journal of Urology·L B LernerS N Rous
Jan 6, 1999·AIDS·K BoubakerA Telenti
Jan 6, 1999·AIDS·G B Scott, R Tuomala
Feb 13, 1999·The New England Journal of Medicine·H HanabusaH Hataya
Feb 3, 2000·Archives of Pathology & Laboratory Medicine·G L HortinJ B Kopp
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A M CattelanP Cadrobbi
Mar 29, 2000·The Journal of Urology·M HammP Rathert
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M JaradatS Moe
Sep 8, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R F GagnonC M Tsoukas
Sep 16, 2000·Current Opinion in Nephrology and Hypertension·A J OlyaeiW M Bennett
Jan 9, 2001·American Journal of Nephrology·R F GagnonC M Tsoukas

❮ Previous
Next ❯

Citations

Sep 28, 2006·Journal of Pharmacokinetics and Pharmacodynamics·Smita A KshirsagarDavide Verotta
Mar 1, 2012·Current HIV/AIDS Reports·Lene RyomJens Lundgren
Sep 14, 2002·Current Infectious Disease Reports·Jeffrey B. Kopp
Apr 5, 2003·Kidney International·Neil J WeinerPaul L Kimmel
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard J Baker, Charles D Pusey
Feb 16, 2007·AIDS·Hassane Izzedine, Gilbert Deray
Mar 23, 2005·Kidney International·Nora FranceschiniWilliam F Finn
Nov 18, 2006·Drugs & Aging·Kelly A Gebo
Apr 9, 2015·Clinical Kidney Journal·Hassane IzzedineFabrice Bonnet
Jun 2, 2007·Expert Opinion on Drug Metabolism & Toxicology·Tim R CresseyKulkanya Chokephaibulkit
Mar 1, 2006·Expert Opinion on Drug Safety·Christina M Wyatt, Paul E Klotman
Jan 20, 2016·Nature Reviews. Nephrology·Ehsan NobakhtPaul L Kimmel
May 16, 2014·Kidney International·Michael J Ross
Dec 17, 2009·Advances in Chronic Kidney Disease·Jennifer Jao, Christina M Wyatt
Nov 18, 2008·Seminars in Nephrology·Mohamed G AttaGregory M Lucas
Jan 25, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rolando Claure-Del GranadoRavindra L Mehta
Jan 22, 2011·Expert Opinion on Pharmacotherapy·Zygimantas C AlsauskasMichael J Ross
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Jeffrey S Berns, Nishaminy Kasbekar
Dec 5, 2013·World Journal of Clinical Cases·Vania GiacometGianvincenzo Zuccotti
Oct 18, 2003·Current Opinion in Nephrology and Hypertension·Giovanni B Fogazzi, Giuseppe Garigali
Jul 7, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Molly C FisherMichael J Ross

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.