Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation

Journal of the American College of Cardiology
Gregory Y H LipLars Hvilsted Rasmussen

Abstract

This study sought to perform an indirect comparison analysis of dabigatran etexilate (2 doses), rivaroxaban, and apixaban for their relative efficacy and safety against each other. Data for warfarin compared against the new oral anticoagulants (OACs) in large phase III clinical trials of stroke prevention in atrial fibrillation (AF) are now available for the oral direct thrombin inhibitor, dabigatran etexilate, in 2 doses (150 mg twice daily [BID], 110 mg BID), and the oral Factor Xa inhibitors, rivaroxaban and apixaban. A "head-to-head" direct comparison of drugs is the standard method for comparing different treatments, but in the absence of such head-to-head direct comparisons, another alternative to assess the relative effect of different treatment interventions would be to perform indirect comparisons, using a common comparator. Nonetheless, any inter-trial comparison is always fraught with major difficulties, and an indirect comparison analysis has many limitations, especially with the inter-trial population differences and thus, should not be overinterpreted. Indirect comparison analysis was performed using data from the published trials. There was a significantly lower risk of stroke and systemic embolism (by 26%) for d...Continue Reading

References

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Feb 12, 2011·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN AVERROES Steering Committee and Investigators
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Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Oct 15, 2011·Stroke; a Journal of Cerebral Circulation·Amitava BanerjeeGregory Y H Lip

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Citations

Apr 27, 2013·European Journal of Clinical Pharmacology·Sebastian Harder, Jochen Graff
Jul 13, 2013·Journal of Thrombosis and Thrombolysis·Sean D PokorneyRichard C Becker
Dec 19, 2012·Internal and Emergency Medicine·Sergio Coccheri, Donatella Orlando
Jun 14, 2013·Current Atherosclerosis Reports·Graeme J Hankey, John W Eikelboom
Jun 12, 2012·Advances in Therapy·Tatjana S PotparaGregory Y H Lip
Aug 21, 2013·Best Practice & Research. Clinical Haematology·Ammar Majeed, Sam Schulman
Aug 21, 2013·Best Practice & Research. Clinical Haematology·Tatjana S Potpara, Gregory Y H Lip
Aug 21, 2013·Best Practice & Research. Clinical Haematology·Anuraag R KansalSonja V Sorensen
Aug 28, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·A John CammUNKNOWN Document Reviewers
Dec 4, 2012·QJM : Monthly Journal of the Association of Physicians·Job Harenberg, Gregory Y H Lip
Oct 8, 2013·The Nurse Practitioner·Leslie L Davis
Jul 13, 2012·Circulation. Cardiovascular Quality and Outcomes·Sebastian SchneeweissJerry Avorn
Feb 6, 2014·Dimensions of Critical Care Nursing : DCCN·Leslie L Davis
May 28, 2014·Revista Española De Cardiología·Ignacio Ferreira-González
Apr 1, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sascha Meyer Dos Santos, Sebastian Harder
Apr 11, 2013·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Maria M FernandezWinghan Jacqueline Kwong
Oct 26, 2012·Current Treatment Options in Neurology·Giuseppe Di PasqualeSimona Gambetti
Aug 30, 2014·European Journal of Clinical Pharmacology·Ophelia Q P YinRaymond Miller
Dec 3, 2014·Cardiology Clinics·Mikhail S Dzeshka, Gregory Y H Lip
Jul 26, 2014·Expert Review of Cardiovascular Therapy·Keitaro SenooGregory Yh Lip
Jun 18, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Wei HeNian-Guang Li
Dec 15, 2015·Annals of Hematology·Jordan K SchaeferWaldemar E Wysokinski
Jan 1, 2015·European Heart Journal. Cardiovascular Pharmacotherapy·Ariel Dogliotti, Robert P Giugliano
May 28, 2014·Thrombosis Research·Deepa Suryanarayan, Sam Schulman
Nov 17, 2012·Lancet Neurology·Mark J AlbertsGraeme J Hankey
Mar 1, 2016·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Luis Alcocer

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