PMID: 9555014May 23, 1998Paper

Indirect dexamethasone down-regulation of the liver fatty acid-binding protein expression in rat liver

Biochimica Et Biophysica Acta
L FoucaudP Besnard

Abstract

The effects of glucocorticoids on the regulation of the liver fatty acid-binding protein (L-FABP) were studied in vivo and in primary culture of hepatocytes in rats. No change in L-FABP cytosolic content and mRNA levels occurred after adrenalectomy. By contrast, a twofold decrease in L-FABP expression was found in dexamethasone (Dex) treated rats. In primary culture of rat hepatocytes, insulin did not modify the L-FABP mRNA levels, whereas Dex produced a significant decrease. This down-regulation was independent of specific glucocorticoid receptors, of alteration in the turnover of L-FABP mRNA and did not require a de novo protein synthesis. However, it was totally prevented when 320 microM oleic acid was added in the culture medium. These findings show that the dex-mediated down-regulation of the L-FABP expression found in vivo is not due to a direct endocrine effect, but is likely secondary to changes in cellular lipid metabolism.

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Citations

Jul 3, 2007·Histochemistry and Cell Biology·S GuilmeauM E Samson-Bouma
Feb 9, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Xiaojuan WangHongchao Jiao
Apr 28, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yuanli CaiHai Lin
Aug 25, 2004·The Journal of Pharmacy and Pharmacology·G Rajaraman, F J Burczynski
Oct 8, 2015·Journal of Lipid Research·GuQi WangFrank J Burczynski
Nov 4, 2017·Biological Trace Element Research·Atefeh BerenjianShokoufe Ghazanfari
Jan 24, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anna M D'souzaMichael C Riddell
Nov 17, 2011·Stress : the International Journal on the Biology of Stress·X J WangH Lin
Feb 8, 2011·Stress : the International Journal on the Biology of Stress·Yuanli CaiHai Lin
Feb 16, 1999·Biochimica Et Biophysica Acta·L FoucaudP Besnard

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