Indirect effects of severe acute respiratory syndrome coronavirus 2 on the kidney in coronavirus disease patients

Clinical Kidney Journal
Aymeric CouturierZiad A Massy

Abstract

Among patients hospitalized for novel coronavirus disease (COVID-19), between 10 and 14% develop an acute kidney injury and around half display marked proteinuria and haematuria. Post-mortem analyses of COVID-19 kidney tissue suggest that renal tubular cells and podocytes are affected. Here we report two cases of collapsing glomerulopathy and tubulointerstitial lesions in living COVID-19 patients. Despite our use of sensitive reverse transcription polymerase chain reaction techniques in this study, we failed to detect the virus in blood, urine and kidney tissues. Our observations suggest that these kidney lesions are probably not due to direct infection of the kidney by severe acute respiratory syndrome coronavirus 2.

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Citations

Sep 10, 2020·Clinical Kidney Journal·Lucia Del Vecchio, Francesco Locatelli
Sep 10, 2020·Clinical Kidney Journal·Raul Fernandez-PradoAlberto Ortiz
Oct 3, 2020·Case Reports in Nephrology·Yannick M NlanduFrançois B Lepira
Dec 15, 2020·Advances in Chronic Kidney Disease·Jia H NgKenar D Jhaveri
Feb 13, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sophie FerlicotUNKNOWN AP-HP/Universities/Inserm COVID-19 research collaboration
Apr 3, 2021·Clinical Kidney Journal·Purva SharmaRimda Wanchoo
Mar 30, 2021·Frontiers in Physiology·Marie-Bénédicte Le StangNahid Tabibzadeh
May 3, 2021·Archives of Virology·Seyed Mohammad Ali HashemiJamal Sarvari
Jun 6, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Muhammad SafdarYasmeen Junejo
Aug 10, 2021·Case Reports in Nephrology·Sasmit RoySreedhar Adapa
Jun 16, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Luise HasslerDaniel Batlle

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Methods Mentioned

BETA
biopsy
circular dichroism
light microscopy
electron microscopy

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