PMID: 7009958Dec 1, 1980Paper

Indirect evidence against a role of the kinin system in the renal hemodynamic effect of captopril in the rat

Kidney International
A MimranM Dupont

Abstract

The effects of acute saralasin (SAR) and captopril (SQ) administration on arterial pressure (AP), plasma renin activity (PRA), urinary excretion of water and electrolytes, glomerular filtration rate (GFR), renal blood flow (RBF), and glomerular blood flow (GBF) distribution (microsphere technique) were assessed in rats with activation of the renal renin and kallikrein systems (that is, chronic sodium depletion). In both groups AP decreased, and PRA and RBF increased markedly. Blood flow to outermost (C1) glomeruli was (in nl/min/g of kidney wt) 270 +/- 35 in SAR and 219 +/- 20 in the SQ group (NS when compared to 208 +/- 9 in control chronically sodium-depleted rats). Blood flow to innermost glomeruli (C4) strikingly increased from 95 +/- 10 (control) to 216 +/- 21 (SAR) and 180 +/- 13 (SQ group). Hence, preferential vasodilatation of innermost glomeruli occurred (C1/C4 ratio of 2.18 +/- 0.27 in control, 1.26 +/- 0.11 in SAR, and 1.25 +/- 0.07 in SQ rats). Chronic (6 days) administration of SQ was associated with a rapid and marked increase in water and sodium excretion. At the end of the study, RBF was higher than control, and GBF distribution was similar to that observed in acutely treated rats (C1/C4 ratio of 1.16 +/- 0.10)....Continue Reading

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Citations

Jan 1, 1987·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·C HallJ Kjekshus
Apr 1, 1986·Clinical and Experimental Pharmacology & Physiology·J ZhuoS L Skinner
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·F Elijovich, L R Krakoff
Jan 1, 1993·Upsala Journal of Medical Sciences·P Hansell
May 31, 1984·The American Journal of Medicine·A MimranD Casellas
Jan 1, 1984·British Journal of Clinical Pharmacology·B Jover, A Mimran
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·M C Lansang, N K Hollenberg

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