Indirect potentiometric titration of sulphamethoxazole in the presence of trimethoprim in co-trimazole tablets using copper based mercury film electrode

Chemical & Pharmaceutical Bulletin
Meeran Mohideen Abdul Kamal NazerP Riyazuddin

Abstract

A simple and rapid indirect potentiometric titration of sulphamethoxazole in the presence of trimethoprim contained in co-trimazole tablets is described. The method is based on the formation of a complex of sulphamethoxazole with a known excess of silver ions and the titration of unreacted silver ion potentiometrically using an inexpensive lab-made copper based mercury film electrode (CBMFE). The titration conditions have been optimized for the determination of 1.0-10.0 mg of sulphamethoxazole in pure and dosage forms. The precision and accuracy of the method have been assessed by the application of lack of fit test and other statistical methods. Overall mean recovery and relative standard deviations obtained were 99.88% and 1.32% (n=7) respectively. No interference was caused by other excipients present in pharmaceutical dosage forms. The application of this method for sulphamethoxazole assay in the presence of trimethoprim in tablets was validated by the comparison of results obtained by the proposed method with that of the British Pharmacopoeia (BP) method using F- and t-statistical tests of significance.

References

Jan 1, 1977·Journal of Pharmaceutical Sciences·M R RodriguezS M Albonico
Sep 1, 1987·Scandinavian Journal of Gastroenterology·H O AdamiA Nyberg
May 20, 1998·Journal of Pharmaceutical and Biomedical Analysis·P Riyazuddin, M M Nazer
Jun 1, 1964·Journal of Pharmaceutical Sciences·G J PAPARIELLOR E HUETTEMANN
Jan 1, 1988·Journal of Pharmaceutical and Biomedical Analysis·J BarbosaV Sanz-Nebot

Citations

Jan 8, 2004·Chemical & Pharmaceutical Bulletin·Meeran Mohideen Abdul Kamal NazerP Riyazuddin

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