Indirect revascularization for nonmoyamoya intracranial arterial stenoses: clinical and angiographic outcomes.

Journal of Neurosurgery
Joshua R DusickNestor R Gonzalez

Abstract

Symptomatic intracranial arterial stenoses have a high rate of recurrent stroke despite medical and endovascular treatments. The authors present clinical and angiographic quantitative outcomes of indirect revascularization for patients with symptomatic intracranial stenosis. Patients treated for symptomatic intracranial arterial stenosis by indirect revascularization were included. The patient population comprised those in whom medical management had failed and for whom endovascular therapy was unsuitable or had failed. Patients underwent encephaloduroarteriosynangiosis (EDAS) with or without bur holes. Preoperative and postoperative angiograms were evaluated for change in caliber of extracranial blood vessels (superficial temporal artery [STA] and middle meningeal artery [MMA]) and for evidence of neovascularization. Thirteen patients underwent EDAS. Ischemic symptoms ceased within the follow-up period in all patients, returning in a delayed fashion in only 2. No other patients had recurrent TIAs or strokes after the initial postoperative period. Donor blood vessels increased in size relative to preoperative sizes in all but 1 case (average increase of 52% for proximal STA [p=0.01], 74% for midpoint of STA [p=0.01], and 84% fo...Continue Reading

Associated Clinical Trials

Mar 27, 2013·Nestor R. Gonzalez, MD, MSCR.Nestor R. Gonzalez, MD, MSCR.

References

Jan 1, 1995·Pediatric Neurosurgery·P D Adelson, R M Scott
Jul 19, 2003·Stroke; a Journal of Cerebral Circulation·Randall T HigashidaUNKNOWN Technology Assessment Committee of the Society of Interventional Radiology
Jul 26, 2003·Stroke; a Journal of Cerebral Circulation·David S Liebeskind
Aug 7, 2003·Journal of Vascular and Interventional Radiology : JVIR·UNKNOWN Technology Assesssment Committees of the American Society of Interventional and Therapeutic Neuroradiology, UNKNOWN Society of Interventional Radiology
Apr 1, 2005·The New England Journal of Medicine·Marc I ChimowitzUNKNOWN Warfarin-Aspirin Symptomatic Intracranial Disease Trial Investigators
Dec 23, 2006·Journal of Neurosurgery·Christian Sainte-RoseMarie Bourgeois
Jun 2, 2007·Stroke; a Journal of Cerebral Circulation·Janice E WilliamsUNKNOWN WASID Investigators
Oct 4, 2008·Stroke; a Journal of Cerebral Circulation·Salina P WaddyMarc Chimowitz
Apr 2, 2009·Neurosurgical Focus·Robert M StarkeE Sander Connolly
May 2, 2009·Stroke; a Journal of Cerebral Circulation·Bolanle M FamakinUNKNOWN WASID Trial Investigators
Oct 8, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Adnan I QureshiOsama O Zaidat
Nov 26, 2009·Annals of Neurology·David S Liebeskind
Dec 16, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David S LiebeskindUNKNOWN Warfarin–Aspirin Symptomatic Intracranial Disease (WASID) Investigators
Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Juan F Arenillas
Mar 26, 2011·Annals of Neurology·David S LiebeskindUNKNOWN Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) Investigators
Sep 9, 2011·The New England Journal of Medicine·Marc I ChimowitzUNKNOWN SAMMPRIS Trial Investigators
Oct 30, 2012·Journal of Neurosurgery·Robert L GrubbUNKNOWN Carotid Occlusion Surgery Study Investigators

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Citations

Oct 19, 2013·Lancet Neurology·Christine A HolmstedtMarc I Chimowitz
Apr 15, 2014·Journal of Neurosurgery·Huai-Yu TongXin-Guang Yu
Oct 10, 2013·Current Cardiology Reports·Tanya N TuranMarc I Chimowitz
Mar 1, 2015·Current Treatment Options in Cardiovascular Medicine·Jessica HannahTanya N Turan
Apr 16, 2016·Expert Review of Neurotherapeutics·Xinyi LengThomas W Leung
Feb 6, 2017·Circulation Research·Chirantan Banerjee, Marc I Chimowitz
Oct 11, 2017·Angiogenesis·Nestor R GonzalezJeffrey Saver
Apr 1, 2020·Continuum : Lifelong Learning in Neurology·Michael F Waters
Oct 30, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Nestor R GonzalezJeffrey L Saver

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Methods Mentioned

BETA
dissection
surgical bypass

Clinical Trials Mentioned

NCT00576693

Software Mentioned

COSS
SAMMPRIS

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