PMID: 3982365Jan 1, 1985

Indirect serum haemagglutinating antibody response to black pigmented Bacteroides during experimental pure infections in rats

Medical Microbiology and Immunology
V PancholiK C Agarwal


The humoral immune response during experimental infection with black pigmented bacteroides was studied by the indirect haemagglutination test. Both Bacteroides melanimogenicus (ATCC 25845) and B. intermedius (ATCC 25611), grown in semi-solid agar culture, produced pure subcutaneous, intra-abdominal and lung infections. In each of these infection models, B. intermedius was found to be more pathogenic than B. melaninogenicus on the basis of gross pathology of the lesion, bacteriological and histopathological findings, and the capacity to produce persistent infection. Cytoplasmic extracts of these strains were used as an antigen for the indirect haemagglutination test. In all the infections, B. intermedius provoked a better and higher antibody response than did B. melaninogenicus, suggesting a potent immunogenic property of the former strain. Peak antibody titres in both groups during all the above infections were seen between the 10th and 15th days post infection (p.i.), which was precisely 3-5 days after peak lesion was achieved. A significant IHA antibody titre persisted up to days 30-37 p.i. These findings suggest that the antibodies to the black pigmented Bacteroides are not protective, but may play a role in the pathogenesis...Continue Reading


Mar 1, 1979·Reviews of Infectious Diseases·A B OnderdonkJ G Bartlett
Mar 1, 1977·The Journal of Infectious Diseases·S M Finegold
Jan 1, 1978·Scandinavian Journal of Infectious Diseases·A Schwan, A C Rydén
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Sep 1, 1976·Infection and Immunity·C B Walker, T D Wilkins
Jan 1, 1970·Journal of Periodontal Research·T Kristoffersen, T Hofstad
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Related Concepts

Antibodies, Bacterial
Antibody Formation
Bacteroides Infections
Lung Diseases
Rats, Laboratory

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