Indirubin derivative E804 inhibits angiogenesis.

BMC Cancer
Eun-Kyung Shin, Jin-Kyung Kim

Abstract

It has previously been shown that indirubin derivative E804 (IDR-E804) blocks signal transducer and activator of transcription-3 signaling in human breast and prostate cancer cells and inhibits Src kinase activity. To further establish its role in angiogenesis, we tested its potential using human umbilical vein endothelial cells (HUVECs) and analyzed the effects of IDR-E804 on cellular and molecular events related to angiogenesis. The anti-angiogenic effects of IDR-E804 were examined by assessing the proliferation, migration and capillary tube formation of HUVECs were induced by vascular endothelial growth factor (VEGF) with or without various concentrations of IDR-E804. The inhibitory effect of IDR-E804 angiogenesis and tumor growth in vivo was also investigated in Balb/c mice subcutaneously transplanted with CT-26 colon cancer cells. IDR-E804 significantly decreased proliferation, migration and tube formation of vascular endothelial growth factor VEGF-treated HUVECs. These effects were accompanied by decreased phosphorylation of VEGF receptor (VEGFR)-2, AKT and extracellular signal regulated kinase in VEGF-treated HUVECs. Intratumor injections of IDR-E804 inhibited the growth of subcutaneously inoculated CT-26 allografts in s...Continue Reading

References

Apr 17, 1997·Nature·W Risau
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Sep 29, 2000·Biochemical Pharmacology·E BerraJ Pouysségur
Apr 17, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·B VailhéJ J Feige
Apr 8, 2003·Current Medicinal Chemistry. Anti-cancer Agents·S ShinkarukG Déléris
Apr 11, 2003·Leukemia & Lymphoma·Zhijian XiaoLingsheng Qian
Apr 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sangkil NamRichard Jove
Jun 2, 2005·Nature Reviews. Cancer·Gillian M TozerBruce C Baguley
Nov 23, 2005·Oncology·Peter Carmeliet
Dec 21, 2005·Journal of Cellular and Molecular Medicine·Anne Marie ByrneJ H Harmey
Dec 13, 2006·Expert Opinion on Investigational Drugs·Alex KiselyovSergey E Tkachenko
Apr 26, 2007·Angiogenesis·Carla CostaRaquel Soares
Jul 20, 2007·Current Treatment Options in Oncology·Elwyn Cabebe, Heather Wakelee
Apr 17, 2008·Environmental Health Perspectives·Partha BasuAaron Barchowsky
Jan 6, 2011·International Journal of Cancer. Journal International Du Cancer·Xiaoli ZhangZhengfang Yi
Feb 22, 2011·Journal of Cellular Biochemistry·Jin-Kyung KimJung Han Yoon Park

❮ Previous
Next ❯

Citations

Nov 3, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·F KosovaZ Arı
Sep 14, 2015·Journal of Molecular Graphics & Modelling·Jaida BegumJoseph M Hayes
Oct 31, 2012·Toxicology and Applied Pharmacology·Abigail S BabcockCharles D Rice
Oct 13, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Tina BlaževićPavel Uhrin
Mar 11, 2015·Journal of Molecular Modeling·Przemysław Czeleń, Beata Szefler
Mar 15, 2015·Bioorganic & Medicinal Chemistry Letters·Yoshimi IchimaruShinichi Miyairi
Nov 16, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·O M ChoiK Y Choi
Mar 3, 2020·Frontiers in Pharmacology·Rongchun WangXue Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Software Mentioned

GraphPad Prism
GraphPad

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.