Indirubin improves antioxidant and anti-inflammatory functions in lipopolysaccharide-challenged mice

Oncotarget
Tianjie QiShuai Li

Abstract

Indirubin, a traditional Chinese medicine formulation from the Muricidae family, has been reported to exhibit abroad anti-cancer and anti-inflammation activities and mediate nuclear factor-κB (NF-κB) signal. Thus, this study aimed to investigate the protective effects of indirubin on LPS-induced acute lung injury and the potential mechanism in mice. The results showed that LPS treatment caused oxidative stress and inflammation in mice. Indirubin alleviated LPS-caused oxidative stress and inflammation via reducing MDA abundance and IL-1β and TNF-α expressions in mice. Meanwhile, indirubin improved lung NO production and inhibited NF-κB activation caused by LPS exposure. In conclusion, indirubin alleviated LPS-induced acute lung injury via improving antioxidant and anti-inflammatory functions, which might be associated with the NO and NF-κB signals.

References

Sep 2, 2004·Journal of Cancer Research and Clinical Oncology·Gerhard EisenbrandStephan Muehlbeyer
Dec 22, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jin-Kyung Kim, Geun-Mook Park
Jan 2, 2014·Pharmacology & Therapeutics·Lifei TangMark T Ziolo
Dec 4, 2014·Respiratory Physiology & Neurobiology·Daniela Mokra, Petra Kosutova
Apr 19, 2015·Expert Opinion on Therapeutic Patents·Nicolas Gaboriaud-KolarAlexios-Leandros Skaltsounis
Aug 1, 2015·Molecular Nutrition & Food Research·Ben McNallyLee D Roberts
Oct 13, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Tina BlaževićPavel Uhrin
Oct 27, 2015·Molecular Nutrition & Food Research·Satoshi FukumitsuHiroko Isoda
Mar 31, 2016·Archives of Pathology & Laboratory Medicine·Yasmeen ButtTimothy Craig Allen
Jul 1, 2016·Molecular Nutrition & Food Research·Neha M SahasrabudhePaul de Vos
Aug 5, 2016·Molecular Nutrition & Food Research·Julia LuettigJörg D Schulzke
Aug 23, 2016·Molecular Nutrition & Food Research·Silvia RodrigoCarlos Bocos

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Citations

Apr 20, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Wenyan GaoYang Gong
Nov 6, 2018·Virulence·Antonia EfstathiouMilena Botelho Pereira Soares
Sep 6, 2018·EMBO Molecular Medicine·Cécile OttenSalim Abdelilah-Seyfried
Sep 12, 2020·Chemical Biology & Drug Design·Bin SunYuwei Wang
Apr 10, 2019·Journal of Biomolecular Structure & Dynamics·Kandasamy SaravananPoomani Kumaradhas
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhiqin XuXinjun Xu
Apr 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huifeng YuanXinwei Han

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Methods Mentioned

BETA
MDA
ELISA
PCR

Software Mentioned

Primer

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