Indium 111 autologous tagged leukocytes in the diagnosis of intraperitoneal sepsis

Archives of Surgery
N L AscherJ McCullough

Abstract

We report the results of a new test, indium oxine in 111 scanning, in the diagnosis of postoperative infection. Indium 111 was used to label autologous polymorphonuclear leukocytes, which when reinjected migrate to sites of infection, inflammation, or both. Standard scintigraphy localizes the labeled inflammatory cells at these sites. Sixty-six scans were performed in 43 surgical patients. Thirty-seven scans were categorized as true-positive; 19 scans were categorized as true-negative. Therefore, the accuracy rate was 85%. Two scans (3%) in one patient represented false-positive results. Two scans (3%) were positive for inflammation but there was no infection present; this group was denoted as equivocal. Six scans (9%) were false-negative; false-negative scans are more likely in old lesions with poor blood supply and in areas that overlap regions of normal uptake. The noninvasive nature of the test, high accuracy rate, and ease of administration make it a potentially useful tool in the diagnosis of postoperative infection.

Citations

Jul 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mikael J PittetRalph Weissleder
Jan 1, 1985·The British Journal of Radiology·J R MorganC B Howard
Apr 1, 1983·Gut·S H SaverymuttuV S Chadwick
Apr 16, 1998·Archives of Disease in Childhood·V AggarwalS V Beath
Jul 1, 1980·World Journal of Surgery·N L AscherR L Simmons
Jul 1, 1980·World Journal of Surgery·A P McDonald, R J Howard
Mar 1, 1986·Digestive Diseases and Sciences·A KeshavarzianH J Hodgson
Jan 1, 1986·European Journal of Nuclear Medicine·H M GoodgoldL D Samuels
Jan 1, 1988·European Journal of Nuclear Medicine·K SeyboldP Bläuenstein
Jan 1, 1982·Gastrointestinal Radiology·G SchneeklothW A Fuchs
Apr 1, 1984·Diseases of the Colon and Rectum·R F Crystal, F Palace
Feb 19, 2013·Seminars in Nuclear Medicine·Charito Love, Christopher J Palestro
Jan 1, 1988·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·S ChowdhuryJ A Katzmann
Oct 1, 1992·Seminars in Nuclear Medicine·A M MelloI R McDougall
Mar 1, 1987·Blood Reviews·A M Peters, S H Saverymuttu
Jul 1, 1984·Seminars in Nuclear Medicine·J P Dutcher
Mar 5, 1981·The New England Journal of Medicine·J P DutcherG S Johnston
May 1, 1987·The Journal of Surgical Research·J A ButlerS E Wilson
Jan 1, 1986·Acta Radiologica: Diagnosis·C LundstedtS E Strand
Aug 19, 2000·The American Journal of Gastroenterology·R D DhekneF L Hochman
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·C R Valeri
Jan 27, 1998·Clinical Nuclear Medicine·G W Burris, B M Gordon
Nov 1, 2018·Bioengineering & Translational Medicine·Matthew WilladsenNatesh Parashurama
Sep 1, 1987·Acta Radiologica·M T SyrjäläJ Gripenberg

Related Concepts

Abscess
Teens
False Negative Reactions
False Positive Reactions
Indium
Inflammation
Leukocytes
Secondary Peritonitis
Postoperative Complications
Radioisotopes

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.