Individual and community predictors of urinary ceftriaxone-resistant Escherichia coli isolates, Victoria, Australia

Antimicrobial Resistance and Infection Control
Kyra Y L Chua, Andrew J Stewardson

Abstract

Ceftriaxone-resistant Enterobacteriaceae are priority pathogens of critical importance. Escherichia coli is the most commonly isolated Enterobacteriaceae. There are few data regarding non-invasive ceftriaxone-resistant E. coli (CR-EC) isolates in the Australian community. We aimed to describe the prevalence, phenotype, geographic variation, and sociodemographic predictors of ceftriaxone-resistance among E. coli isolates recovered from urine specimens. In August 2017, we prospectively analysed E. coli isolates recovered from urine specimens submitted to Dorevitch Pathology (Victoria, Australia), a laboratory that services patients in the community and hospitals. In addition to patient-level predictors of ceftriaxone resistance, we mapped patient postcodes to community-level indicators including Index of Relative Socioeconomic Deprivation, remoteness, and proportion of residents born overseas. We used Poisson regression with log link and robust standard errors to quantify the association between ceftriaxone resistance and patient- and community-level factors. We included 6732 non-duplicate E. coli isolates. Most (89.2%, 6008/6732) were obtained from female patients. Median age was 56 years (IQR, 32-74). Most patients (90.5%, 5789...Continue Reading

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Citations

Aug 7, 2020·International Journal of Environmental Research and Public Health·Kar Hui OngKyaw Thu Aung
Dec 12, 2020·Antimicrobial Resistance and Infection Control·Ebtisam S MohamedSoha S Abdelrahim
Jul 1, 2021·Open Forum Infectious Diseases·Joan A CaseySara Y Tartof
Aug 1, 2021·Pharmacology Research & Perspectives·Ashagrachew TewabeGebremariam Birhanu

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