Jan 3, 2001

Individual and community risks of measles and pertussis associated with personal exemptions to immunization

JAMA : the Journal of the American Medical Association
D R FeikinR E Hoffman


The risk of vaccine-preventable diseases among children who have philosophical and religious exemptions from immunization has been understudied. To evaluate whether personal exemption from immunization is associated with risk of measles and pertussis at individual and community levels. Population-based, retrospective cohort study using data collected on standardized forms regarding all reported measles and pertussis cases among children aged 3 to 18 years in Colorado during 1987-1998. Relative risk of measles and pertussis among exemptors and vaccinated children; association between incidence rates among vaccinated children and frequency of exemptors in Colorado counties; association between school outbreaks and frequency of exemptors in schools; and risk associated with exposure to an exemptor in measles outbreaks. Exemptors were 22.2 times (95% confidence interval [CI], 15.9-31.1) more likely to acquire measles and 5.9 times (95% CI, 4.2-8.2) more likely to acquire pertussis than vaccinated children. After adjusting for confounders, the frequency of exemptors in a county was associated with the incidence rate of measles (relative risk [RR], 1.6; 95% CI, 1.0-2.4) and pertussis (RR, 1.9; 95% CI, 1.7-2.1) in vaccinated children....Continue Reading

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Mentioned in this Paper

Disease Outbreaks
Pertussis Vaccine
Immunization Domain
Schools, Secondary
Whooping Cough due to Unspecified Organism
Religion and Medicine
Philosophy, Medical

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