Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced Obesity

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Mike J F RobinsonCarrie R Ferrario

Abstract

Pavlovian cues associated with junk-foods (caloric, highly sweet, and/or fatty foods), like the smell of brownies, can elicit craving to eat and increase the amount of food consumed. People who are more susceptible to these motivational effects of food cues may have a higher risk for becoming obese. Further, overconsumption of junk-foods leading to the development of obesity may itself heighten attraction to food cues. Here, we used a model of individual susceptibility to junk-foods diet-induced obesity to determine whether there are pre-existing and/or diet-induced increases in attraction to and motivation for sucrose-paired cues (ie, incentive salience or 'wanting'). We also assessed diet- vs obesity-associated alterations in mesolimbic function and receptor expression. We found that rats susceptible to diet-induced obesity displayed heightened conditioned approach prior to the development of obesity. In addition, after junk-food diet exposure, those rats that developed obesity also showed increased willingness to gain access to a sucrose cue. Heightened 'wanting' was not due to individual differences in the hedonic impact ('liking') of sucrose. Neurobiologically, Mu opioid receptor mRNA expression was lower in striatal 'hot-...Continue Reading

References

Sep 6, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry E LevinWilliam A Banks
Dec 18, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Deborah J CleggBarry E Levin
Nov 1, 2005·Physiology & Behavior·Peter C Holland, Gorica D Petrovich
May 19, 2007·Brain, Behavior and Evolution·K W S AshwellC R R Watson
Jul 10, 2007·Neuroscience and Biobehavioral Reviews·Nicole M AvenaBartley G Hoebel
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Terry E Robinson, Kent C Berridge
Jul 29, 2008·Neuropharmacology·Paul Vezina, Marco Leyton
Jun 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Dagher
Nov 11, 2009·Obesity Surgery·Kimberley E SteeleDean F Wong
Jan 13, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N R LenardH-R Berthoud
Apr 6, 2011·Archives of General Psychiatry·Ashley N GearhardtKelly D Brownell
May 12, 2011·Physiology & Behavior·Sarah L ParylakEric P Zorrilla
Aug 19, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrew C ShinHans-Rudolf Berthoud
Oct 21, 2011·Nature Reviews. Neuroscience·Paul J Kenny
Apr 20, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kathryn E DemosWilliam M Kelley
Jul 18, 2012·The Proceedings of the Nutrition Society·Hans-Rudolf Berthoud
Sep 25, 2012·Current Biology : CB·Alexandra G DiFeliceantonioKent C Berridge
Sep 29, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N D VolkowR D Baler
Oct 20, 2012·Behavioural Brain Research·Patrick AnselmeKent C Berridge
Dec 15, 2012·Neuroscience and Biobehavioral Reviews·Eric SticeWayne E Pratt
Feb 5, 2013·Biological Psychiatry·Nora D VolkowRuben D Baler
Mar 7, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chao-Yi Ho, Kent C Berridge
Jun 28, 2014·Progress in Brain Research·Quentin J M HuysShelly B Flagel

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Citations

Feb 2, 2016·Biological Psychiatry·Robyn Mary BrownPeter William Kalivas
Nov 27, 2015·Social Cognitive and Affective Neuroscience·Francesco VersaceSusan M Schembre
Oct 27, 2015·CNS Spectrums·Chiara Giuliano, Pietro Cottone
Jul 8, 2015·Physiology & Behavior·Hallie S Wald, Kevin P Myers
Mar 18, 2016·Brain Structure & Function·Paige M DingessTravis E Brown
Oct 1, 2015·Addiction Biology·Royi BarneaAron Weller
May 18, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Esther M van der ZwaalMireille J Serlie
Jun 5, 2016·Physiology & Behavior·Robert A BoakesMichael D Kendig
Jul 8, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Max F OginskyCarrie R Ferrario
Dec 7, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Catherine F MoorePietro Cottone
Mar 16, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paige M DingessTravis E Brown
Apr 24, 2017·Current Obesity Reports·Robert TurtonJanet Treasure
Apr 4, 2017·European Eating Disorders Review : the Journal of the Eating Disorders Association·Erica M Schulte, Ashley N Gearhardt
Jan 4, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer L ThompsonStephanie L Borgland
Feb 2, 2020·Cellular and Molecular Life Sciences : CMLS·Ranier GutierrezSidney A Simon
Jul 31, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yanaira Alonso-CaraballoCarrie R Ferrario
Dec 3, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carrie R Ferrario
Dec 22, 2017·European Eating Disorders Review : the Journal of the Eating Disorders Association·Erica M Schulte, Ashley N Gearhardt
Apr 4, 2019·The Behavioral and Brain Sciences·Patrick Anselme, Onur Güntürkün
Mar 15, 2018·Frontiers in Pharmacology·Catherine F MoorePietro Cottone
Sep 1, 2018·Frontiers in Psychiatry·Alisa R KosheleffSean B Ostlund
Apr 9, 2020·The Journal of Pharmacology and Experimental Therapeutics·Jeremiah RamosKatherine M Serafine
Aug 28, 2020·Physiology & Behavior·Ileana Morales, Kent C Berridge
Sep 29, 2019·Annual Review of Psychology·Ivan E de AraujoDana M Small
Mar 5, 2018·Physiology & Behavior·A C ReicheltK A Page
Apr 17, 2021·Neuropharmacology·Katherine M SerafineEric P Zorrilla

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