Aug 2, 2018

Individual differences in dopamine are associated with reward discounting in clinical groups but not in healthy adults

BioRxiv : the Preprint Server for Biology
Jaime J CastrellonGregory R Samanez-Larkin


Some people are more willing to make immediate, risky, or costly reward-focused choices than others, which has been hypothesized to be associated with individual differences in dopamine (DA) function. In two studies using PET imaging, one empirical (Study 1: N=144 males and females) and one meta-analytic (Study 2: N=307), we sought to characterize associations between individual differences in DA and time, probability, and physical effort discounting in human adults. Study 1 demonstrated that individual differences in DA D2-like receptors were not significantly associated with time, probability, or physical effort discounting of monetary rewards in healthy humans. Meta-analytic results for temporal discounting corroborated our empirical finding for minimal effect of DA measures on discounting in healthy individuals, but suggested that associations between individual differences in DA and reward discounting depend on clinical features. Addictions were characterized by negative correlations between DA and discounting but other clinical conditions like Parkinson's Disease, obesity, and ADHD were characterized by positive correlations between DA and discounting. Together the results suggest that trait differences in discounting in ...Continue Reading

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Mentioned in this Paper

Meta Analysis (Statistical Procedure)
Positron-Emission Tomography
Dopamine D2 Receptor
Displacement of Abomasum
Dopamine Measurement

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