Individual differences in locomotor reactivity to a novel environment and sensitivity to opioid drugs in the rat. II. Agonist-induced antinociception and antagonist-induced suppression of fluid consumption

Psychopharmacology
David A WhiteStephen G Holtzman

Abstract

In an animal model for vulnerability to drug abuse, rats that are more reactive to a novel environment (high responders, HRs) are more sensitive to behavioral effects of psychostimulants than are less reactive rats (low responders, LRs). In a companion article, we reported that HRs and LRs differ in sensitivity to morphine-induced locomotor sensitization. We tested whether LRs and HRs also differ in sensitivity to opioid-induced antinociception and opioid antagonist-induced suppression of fluid consumption. LRs and HRs were categorized based on motor responses to novelty during a 30-min session. Responses to nociceptive stimuli of varied intensities were measured using the tail-flick and hot-plate tests alone or following cumulative doses of morphine (1.0-12 mg/kg), buprenorphine (0.025-0.6 mg/kg), or etorphine (0.25-6.0 microg/kg). Potential changes in endogenous opioid-mediated reward systems were tested using naltrexone-induced (0.01-30 mg/kg) suppression of drinking either water following 24-h deprivation or sweetened condensed milk in a non-deprived state. These effects were further examined following 2 weeks of daily access to sweetened condensed milk. At the lowest stimulus intensity tested, HRs had significantly shorter...Continue Reading

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Citations

Sep 1, 2005·Psychopharmacology·Alessandra ConcasGiovanni Biggio
Jul 29, 2008·Behavioural Brain Research·M CecchiH Akil
Jan 22, 2008·Pharmacology, Biochemistry, and Behavior·David A WhiteStephen G Holtzman
Jun 5, 2007·Neurobiology of Learning and Memory·Antoine G AlmonteStephen F Traynelis
Jun 26, 2012·Alcoholism, Clinical and Experimental Research·Jessica R BarsonSarah F Leibowitz
Mar 27, 2007·Brain Research·David A WhiteStephen G Holtzman
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Dec 12, 2007·Journal of Pharmacological Sciences·Wakako HamabeShiroh Kishioka

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