Individual differences in peripheral blood immunological and hormonal measures in adult male rhesus macaques (Macaca mulatta): evidence for temporal and situational consistency

American Journal of Primatology
John P CapitanioN W Lerche

Abstract

A growing body of research has indicated that consistent individual differences exist in physiological systems with which the immune system interacts. Few data have been reported that demonstrate stable individual differences in immunological measures, however. In the present study, enumerative measures of immune system activity were examined in 36 adult male rhesus macaques over a 13 month period under baseline conditions as well as under conditions of pharmacological and physical challenge. Blood samples were assayed for plasma concentrations of ACTH and cortisol, as well as neutrophil, total lymphocyte, CD4+ and CD8+ lymphocyte numbers, and the CD4/CD8 ratio. Analyses revealed that individual differences in the CD4/CD8 ratio and, to a lesser extent, plasma ACTH and cortisol concentrations, and neutrophil and CD4+ lymphocyte numbers were consistent across situations and times, despite changes in mean values during the various blood sampling sessions. The results suggest that the CD4/CD8 ratio might be considered trait-like and a useful immunological measure of biobehavioral organization.

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Citations

Jan 13, 2005·American Journal of Primatology·David Glenn Smith, John McDonough
Sep 5, 2003·Physiology & Behavior·A Courtney DeVriesCourtney E Detillion
Apr 20, 2000·Applied Animal Behaviour Science·S J SchapiroK J Sastry
Oct 17, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Oliver J BoschLarry J Young
Nov 17, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Barney Luttbeg, Andrew Sih
May 26, 2009·Brain, Behavior, and Immunity·Suzanne C Segerstrom, Mark L Laudenslager
Jun 26, 2007·Psychoneuroendocrinology·A Courtney DeVriesJessica K Alexander
Jul 3, 2007·Psychoneuroendocrinology·Karen J ParkerDavid M Lyons
May 23, 2007·Journal of Medical Primatology·S P LeiboCatherine A VandeVoort
Feb 6, 2016·American Journal of Primatology·Darcy L HannibalJohn Capitanio
Jan 21, 2003·The Journal of General Virology·J L HuffP A Barry
Jan 7, 2003·Internal Medicine Journal·I D Lewis
Apr 16, 2005·Developmental Psychobiology·John P CapitanioNicole Maninger
Nov 5, 2008·Expert Review of Vaccines·Silvia BaroncelliAndrea Cara

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