Individual differences in rats' reactivity to novelty and the unconditioned and conditioned locomotor effects of methamphetamine

Pharmacology, Biochemistry, and Behavior
R A Bevins, Jessica L Peterson

Abstract

Rat's reactivity to inescapable novelty can predict the subsequent psychomotor effects of many stimulants. This relation has not been examined for methamphetamine. Experiment 1 assessed the locomotor effects of methamphetamine (0.0625-1.0 mg/kg). On average, acute administration of methamphetamine (0.25, 0.5, and 1 mg/kg) had a stimulant effect on activity; locomotor sensitization was seen after repeated administration of 0.5 and 1 mg/kg. In a subsequent drug-free test, rats that had the locomotor chamber paired with 0.25, 0.5, or 1 mg/kg methamphetamine on eight separate occasions were more active than controls--conditioned hyperactivity. Experiment 2 used the 0.5-mg/kg dose to examine whether forced novelty exposure (novelty-induced activity) or free-choice novelty (approach to novel environment or object interaction) was predictive of methamphetamine's psychomotor effects. Only reactivity to inescapable novelty was systematically correlated with methamphetamine-induced activity. Rats more reactive to novelty [high responders (HR)] were more active to the acute and chronic methamphetamine challenge. Furthermore, these HR showed more conditioned hyperactivity than low responders (LR). Although acute methamphetamine did not hav...Continue Reading

Citations

Aug 13, 2013·Psychopharmacology·Anthony J HutchinsonMargarita L Dubocovich
Jul 6, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kathleen M GrantRick A Bevins
Mar 31, 2011·Behavioural Pharmacology·Anthony Sean Rauhut, Victoria Bialecki
Mar 13, 2012·Pharmacology, Biochemistry, and Behavior·Michelle C CyrMichael M Morgan
Dec 28, 2010·Neuroscience and Biobehavioral Reviews·Susan Schenk
Jan 19, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ning ZhuDiana L Dow-Edwards
Dec 2, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jenny L Wiley, Rhys L Evans
Nov 13, 2007·Drug and Alcohol Dependence·Erin C Stoffel, Kathryn A Cunningham
Feb 16, 2007·Physiology & Behavior·Jamie L Wilkinson, Rick A Bevins
Dec 18, 2012·Alcoholism, Clinical and Experimental Research·Kenneth J D Allen, Frances H Gabbay
Oct 12, 2005·Pharmacology, Biochemistry, and Behavior·Robert J CareyArielle Shanahan

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