Individual differences in the cardiovascular responses to tonic muscle pain: parallel increases or decreases in muscle sympathetic nerve activity, blood pressure and heart rate

Experimental Physiology
Azharuddin FazalbhoyV G Macefield

Abstract

We recently showed that acute muscle pain, induced by bolus intramuscular injection of hypertonic saline, causes a sustained increase in muscle sympathetic nerve activity (MSNA) and a modest increase in blood pressure and heart rate. However, it is not known whether long-lasting (tonic) pain, which more closely resembles chronic pain, causes a sustained increase in MSNA and blood pressure. We tested this hypothesis by recording MSNA in 12 healthy subjects. Tonic pain was induced for ~60 min by slow intramuscular infusion of hypertonic saline (7%) into the ipsilateral tibialis anterior muscle. Pain was sustained at a tolerable level (5/10 to 6/10 on a visual analog scale). Seven subjects showed progressive increases in mean MSNA amplitude during tonic pain, increasing to 154 ± 17% (SEM) at 45 min and remaining essentially constant for the duration of the infusion. In these subjects, blood pressure and heart rate also increased. Conversely, for the other five subjects MSNA showed a progressive decline, with a peak fall of 67 ± 11% at 40 min; blood pressure and heart rate also fell in these subjects. We conclude that tonic muscle pain has long-lasting effects on the sympathetic control of blood pressure, causing a sustained increa...Continue Reading

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Citations

Jul 10, 2012·Journal of Behavioral Medicine·Else-Marie Elmholdt JegindøTroels Staehelin Jensen
Jan 31, 2014·Experimental Brain Research·Azharuddin FazalbhoyVaughan G Macefield
Aug 29, 2012·Experimental Brain Research·Troy K RubinVaughan G Macefield
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Dec 29, 2020·Frontiers in Medicine·Francesca IngegnoliRoberto Caporali
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