Dec 3, 2019

Individual differences in successful self-regulation of the dopaminergic midbrain

BioRxiv : the Preprint Server for Biology
Lydia HellrungPhilippe N. Tobler

Abstract

The dopaminergic midbrain is associated with brain functions, such as reinforcement learning, motivation and decision-making that are often disturbed in neuropsychiatric disease. Previous research has shown that activity in the dopaminergic midbrain can be endogenously modulated via neurofeedback, suggesting potential for non-pharmacological interventions. However, the robustness of endogenous modulation, a requirement for clinical translation, is unclear. Here, we examined how self-modulation capability relates to regulation transfer. Moreover, to elucidate potential mechanisms underlying successful self-regulation, we studied individual prediction error coding, and, during an independent monetary incentive delay (MID) task, individual reward sensitivity. Fifty-nine participants underwent neurofeedback training either in a veridical or inverted feedback group. Successful self-regulation was associated with post-training activity within the cognitive control network and accompanied by decreasing prefrontal prediction error signals and increased prefrontal reward sensitivity in the MID task. The correlative link of dopaminergic self-regulation with individual differences in prefrontal prediction error and reward sensitivity sugg...Continue Reading

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Mentioned in this Paper

Research
Biological Regulation
Decision Making
Regulation of Biological Process
Brain
Protein Biosynthesis
Participant
Psychological Reinforcement
Brain Function
Learning

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