Individual differences in wheel-running rhythms are related to temporal and spatial patterns of activation of orexin A and B cells in a diurnal rodent (Arvicanthis niloticus)

Neuroscience
Joshua P Nixon, L Smale

Abstract

This study investigated the relationship between the orexins and patterns of activity in the diurnal Nile grass rat, Arvicanthis niloticus. Some individuals of this species switch to a more nocturnal pattern when given access to a running wheel, while others continue to be most active during the day. In both day- and night-active grass rats, the percentages of orexin A (OXA) and orexin B (OXB) cells expressing Fos were highest when animals were actively running in wheels. In night-active animals, removal of the running wheel significantly decreased OXA and OXB cell Fos expression. Additionally, in night-active animals, clear regional differences were apparent. In these animals the presence of a wheel induced higher percentages of Fos in both OXA and OXB cells in medial regions of the lateral hypothalamus than in lateral regions. In night-active animals without access to wheels, this medial-lateral gradient was present only in OXA cells. No regional differences were observed in day-active animals. This study demonstrates that individual differences in the patterns of activation of OXA and OXB cell populations are related to differences in the temporal pattern of wheel running. We also present evidence that orexin cells have proj...Continue Reading

References

Jan 1, 1994·Brain Research. Brain Research Reviews·L P Morin
Apr 29, 1998·Journal of Biological Rhythms·D R Weaver
Jun 10, 1998·Biology of the Cell·M H HastingsI Schurov
Jan 8, 1999·Biochemical and Biophysical Research Communications·M Lubkin, A Stricker-Krongrad
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y DateM Nakazato
May 13, 1999·Brain Research·T NambuK Goto
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·J J HaganN Upton
Oct 8, 1999·Journal of Biological Rhythms·J A BlanchongL Smale
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·L de Lecea, J G Sutcliffe
May 23, 2001·The Journal of Comparative Neurology·J N MarcusJ K Elmquist
Jan 5, 2002·Journal of Chemical Neuroanatomy·Colleen M Novak, H Elliott Albers
Feb 7, 2002·Regulatory Peptides·Catherine M KotzChuanFeng Wang
Jul 31, 2003·European Journal of Endocrinology·M L Raffin-SansonX Bertagna
Dec 9, 2003·Depression and Anxiety·Christopher L DrakeThomas Roth
Feb 18, 2004·Journal of Biological Rhythms·Uwe Redlin, N Mrosovsky

❮ Previous
Next ❯

Citations

Nov 5, 2005·Brain Research. Brain Research Reviews·Ralph E Mistlberger
May 16, 2013·Integrative and Comparative Biology·Benjamin L SmarrHoracio O de la Iglesia
Dec 6, 2008·Molecular Brain·Oliver J MarstonHugh D Piggins
Mar 1, 2008·Critical Reviews in Biochemistry and Molecular Biology·Vasu SheebaTodd C Holmes
Apr 11, 2009·Chronobiology International·Rotem CohenNoga Kronfeld-Schor
Jul 7, 2012·Experimental Neurology·Lawrence P Morin
Dec 1, 2010·Behavioural Brain Research·R A Hut, E A Van der Zee
Apr 7, 2010·Physiology & Behavior·Anton J W ScheurinkPer Södersten
Aug 6, 2009·Frontiers in Neuroendocrinology·Miguel LópezCarlos Diéguez
Oct 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·David B HoganLilian Thorpe
May 1, 2007·Brain Research·Pingfu FengKingman P Strohl
Feb 19, 2008·The European Journal of Neuroscience·Ian C WebbRalph E Mistlberger
Jul 19, 2012·Annals of the New York Academy of Sciences·Catherine KotzCharles Billington
Jun 22, 2006·Physiology & Behavior·Catherine M Kotz
Mar 16, 2011·Physiology & Behavior·Alexandra Castillo-Ruiz, Antonio A Nunez
Apr 12, 2015·Brain Research·L M G CamposL Pinato
Sep 22, 2010·Chronobiology International·Beatriz Baño OtaloraMaria Angeles Rol
May 26, 2017·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Juanita BacsuBonnie Jeffery

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.