Individual housing from rearing modifies the performance of young rats on the elevated plus-maze apparatus

Physiology & Behavior
N L Da SilvaG S Morato

Abstract

Previous studies from our laboratory have demonstrated that male and female rats exhibit a differential pattern of behavior in the elevated plus-maze as a function of age. In the present study, the influence of individual housing conditions on young animals treated with one of two classical anxioselective drugs, diazepam or pentylenetetrazole, was investigated in the elevated plus-maze. In Experiment I, males and females were housed for 30 days after weaning either individually or in groups, and tested in the elevated plus-maze at 60 days of age. In Experiment 2, the effects of diazepam (0.75 or 1.0 mg/kg) or of pentylenetetrazole (20 or 30 mg/kg) on the behavior of isolated or grouped rats were studied at 60 days of age in the elevated plus-maze. The results show that isolated housed animals tested with diazepam at 60 days of age exhibited increased frequency and time spent on the open arms of the apparatus compared to control rats. The effect of diazepam was not observed in grouped animals tested at 60 days of age. Pentylenetetrazole produced a decrease in the frequency and time spent on the open arms. This effect was more prominent in grouped animals. The results suggest that 60-day-old rats deprived of playfighting experien...Continue Reading

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Citations

Jan 22, 2003·Physiology & Behavior·Miriam Mendonça Morato AndradeTelma Gonçalves Carneiro Spera de Andrade
Mar 27, 2001·British Journal of Pharmacology·S CheetaS E File
Feb 22, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yukio AgoToshio Matsuda
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Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Farhan MohammadAdam Claridge-Chang
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Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eszter Majercsik, József Haller
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Sep 12, 2006·Neuroscience and Behavioral Physiology·A Yu Shishelova
Jun 2, 2009·Ecotoxicology and Environmental Safety·K J A RodriguesL R F Faro

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