Individual meaning-centered psychotherapy for the treatment of psychological and existential distress: A randomized controlled trial in patients with advanced cancer

Cancer
William BreitbartNatalie Fenn

Abstract

Patients with advanced cancer have high rates of psychological distress, including depression, anxiety, and spiritual despair. This study examined the effectiveness of individual meaning-centered psychotherapy (IMCP) in comparison with supportive psychotherapy (SP) and enhanced usual care (EUC) in improving spiritual well-being and quality of life and reducing psychological distress in patients with advanced cancer. Patients (n = 321) were randomly assigned to IMCP (n = 109), SP (n = 108), or EUC (n = 104). Assessments were conducted at 4 time points: before intervention, midtreatment (4 weeks), 8 weeks after treatment, and 16 weeks after treatment. Significant treatment effects (small to medium in magnitude) were observed for IMCP, in comparison with EUC, for 5 of 7 outcome variables (quality of life, sense of meaning, spiritual well-being, anxiety, and desire for hastened death), with Cohen's d ranging from 0.1 to 0.34; no significant improvement was observed for patients receiving SP (d < 0.15 and P > .05 for all variables). The effect of IMCP was significantly greater than the effect of SP for quality of life and sense of meaning (d = 0.19) but not for the remaining study variables. This study provides further support for t...Continue Reading

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Citations

Jan 3, 2019·Palliative & Supportive Care·William Breitbart
Jan 22, 2019·Pediatric Blood & Cancer·Bryan A SiskJennifer W Mack
Jan 27, 2019·Palliative & Supportive Care·Wendy G LichtenthalWilliam Breitbart
May 12, 2019·Psycho-oncology·Irene TeoGeok Ling Lee
Nov 21, 2019·The American Journal of Bioethics : AJOB·Rebecca M SaracinoHarvey Max Chochinov
Feb 6, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary RodinCarmine Malfitano
Dec 12, 2019·Psycho-oncology·Jordan A GittzusJennifer W Mack
Mar 3, 2020·Palliative & Supportive Care·Melissa Masterson-DuvaWilliam Breitbart
Oct 31, 2019·Journal of Palliative Medicine·Rosario Costas-MuñizFrancesca Gany
Jun 3, 2020·Journal of Medical Internet Research·Kathleen YinAnnie Y S Lau
Jul 10, 2018·Current Opinion in Psychiatry·Pia von Blanckenburg, Nico Leppin
Apr 27, 2019·Frontiers in Psychiatry·Annina Seiler, Josef Jenewein
Sep 12, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Xiaocheng LiuWenjuan Ying
Aug 25, 2020·Journal of Contemporary Psychotherapy·William C SandersonZoe Stout
Mar 6, 2019·Palliative & Supportive Care·William Breitbart
Nov 30, 2019·Journal of Psychosocial Oncology·Mary Vining RadomskiBarbara L Zust
Sep 17, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Evan T HallLidia Schapira
Dec 3, 2020·BMJ Supportive & Palliative Care·Natasha G MichaelDavid Kissane
Aug 3, 2020·Journal of Pain and Symptom Management·Rebecca M SaracinoWilliam Breitbart
Jan 13, 2021·Palliative & Supportive Care·Andrea BoveroRiccardo Torta
Jan 14, 2021·Journal of Religion and Health·O Garduño-OrtegaR Costas-Muñiz
Feb 14, 2021·British Journal of Health Psychology·Ifeanyichukwu Anthony Ogueji
Nov 19, 2020·American Journal of Psychotherapy·Rickinder SethiSarah Hales
Jan 12, 2021·International Journal of Cognitive Therapy·Thomas HeidenreichRoss Menzies
Feb 26, 2021·American Journal of Health Promotion : AJHP·Nicholas Manco, Sherry Hamby
Mar 16, 2021·Journal of Palliative Medicine·Minurika PerusingheBrett McDermott
Mar 26, 2021·Journal of Psychosocial Oncology·Mark William FlanaganMatthew Lee Smith
Sep 15, 2020·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Angelo Braga MendonçaAdriana de Oliveira Martins

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