Individual-Molecule Perspective Analysis of Chemical Reaction Networks: The Case of a Light-Driven Supramolecular Pump

Angewandte Chemie
Andrea SabatinoDiego Frezzato

Abstract

The first study in which stochastic simulations of a two-component molecular machine are performed in the mass-action regime is presented. This system is an autonomous molecular pump consisting of a photoactive axle that creates a directed flow of rings through it by exploiting light energy away from equilibrium. The investigation demonstrates that the pump can operate in two regimes, both experimentally accessible, in which light-driven steps can be rate-determining or not. The number of photons exploited by an individual molecular pump, as well as the precision of cycling and the overall efficiency, critically rely on the operating regime of the machine. This approach provides useful information not only to guide the chemical design of a self-assembling molecular device with desired features, but also to elucidate the effect of the environment on its performance, thus facilitating its experimental investigation.

References

Sep 18, 1999·Nature·N KoumuraB L Feringa
Jun 20, 2001·Accounts of Chemical Research·C BustamanteG Oster
Dec 14, 2006·Annual Review of Physical Chemistry·Anatoly B Kolomeisky, Michael E Fisher
Feb 3, 2007·Nature·Viviana SerreliDavid A Leigh
Sep 20, 2007·Physical Chemistry Chemical Physics : PCCP·R Dean Astumian
May 31, 2008·Angewandte Chemie·Stephen Mann
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Edzard M GeertsemaBen L Feringa
Jun 2, 2010·Biophysical Journal·R Dean Astumian
Jul 16, 2010·Methods in Enzymology·Jeffrey R MoffittCarlos Bustamante
Nov 26, 2011·Chemical Society Reviews·Ali CoskunBartosz A Grzybowski
Aug 11, 2012·Journal of Molecular Biology·Christoph RatzkeThorsten Hugel
Nov 13, 2012·Molecular Cell·Zhixiong Xu, Gary Felsenfeld
May 10, 2013·The Journal of Chemical Physics·Daniel T GillespieLinda R Petzold
May 23, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Lorenzo MoroFrancesco Zerbetto
Sep 12, 2014·Journal of the American Chemical Society·Lutz Greb, Jean-Marie Lehn
Nov 25, 2014·Nature Nanotechnology·Edie Sevick
Nov 25, 2014·Nature Nanotechnology·Giulio RagazzonAlberto Credi
Feb 6, 2015·Nature Nanotechnology·Elio Mattia, Sijbren Otto
May 20, 2015·Nature Nanotechnology·Chuyang ChengJ Fraser Stoddart
Aug 12, 2015·The Journal of Physical Chemistry Letters·Shirong BaiRex T Skodje
Sep 9, 2015·Chemical Reviews·Sundus Erbas-CakmakAlina L Nussbaumer
Dec 15, 2015·Beilstein Journal of Nanotechnology·Giulio RagazzonAlberto Credi
Dec 25, 2015·Nano Letters·Edith M Sevick, David R M Williams
Jun 10, 2016·Nature·Miriam R WilsonDavid A Leigh
Mar 25, 2017·Chemical Society Reviews·Cristian PezzatoR Dean Astumian
Apr 19, 2017·Chemical Society Reviews·Gonen AshkenasyAnnette F Taylor
Apr 21, 2017·Chemical Society Reviews·Salma KassemDavid A Leigh
Aug 2, 2017·The Journal of Physical Chemistry Letters·Shirong Bai, Rex T Skodje
Oct 21, 2017·Science·Sundus Erbas-CakmakMiriam R Wilson
May 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Christopher R BensonAmar H Flood
Sep 19, 2018·Nature Nanotechnology·Giulio Ragazzon, Leonard J Prins
Apr 8, 2019·The Journal of Chemical Physics·Andrea Sabatino, Diego Frezzato

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Citations

Oct 4, 2019·Chemical Communications : Chem Comm·Jessica GroppiAlberto Credi
Sep 3, 2019·Angewandte Chemie·Syed Pavel AfroseDibyendu Das
Apr 18, 2021·Physical Review. E·Diego Frezzato
May 6, 2021·Chemistry : a European Journal·Stefano CorraAlberto Credi
Jul 21, 2021·Journal of the American Chemical Society·Martina CantonAlberto Credi
Aug 14, 2020·Journal of the American Chemical Society·Qing-Hui GuoJ Fraser Stoddart

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