Individual participant data pooled-analysis of risk factors for recurrence after neoadjuvant radiotherapy and transanal local excision of rectal cancer: the PARTTLE study

Techniques in Coloproctology
A ArezzoM Morino

Abstract

An organ-preserving strategy may be a valid alternative in the treatment of selected patients with rectal cancer after neoadjuvant radiotherapy. Preoperative assessment of the risk for tumor recurrence is a key component of surgical planning. The aim of the present study was to increase the current knowledge on the risk factors for tumor recurrence. The present study included individual participant data of published studies on rectal cancer surgery. The literature was reviewed according to according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Individual Participant Data checklist (PRISMA-IPD) guidelines. Series of patients, whose data were collected prospectively, having neoadjuvant radiotherapy followed by transanal local excision for rectal cancer were reviewed. Three independent series of univariate/multivariate binary logistic regression models were estimated for the risk of local, systemic and overall recurrence, respectively. We identified 15 studies, and 7 centers provided individual data on 517 patients. The multivariate analysis showed higher local and overall recurrences for ypT3 stage (OR 4.79; 95% CI 2.25-10.16 and OR 6.43 95% CI 3.33-12.42), tumor size after radiotherapy > 10 mm (OR 5.8...Continue Reading

References

Feb 19, 2009·The British Journal of Surgery·S P BachUNKNOWN Association of Coloproctology of Great Britain and Ireland Transanal Endoscopic Microsurgery (TEM) Collaboration
Sep 17, 2010·The British Journal of Surgery·F M SmithD C Winter
Jan 22, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Krzysztof BujkoAnna Rychter
Nov 10, 2013·Diseases of the Colon and Rectum·Salvatore PucciarelliClaudio Coco
Jul 30, 2014·World Journal of Gastroenterology : WJG·Mario GuerrieriMaddalena Baldarelli
Oct 7, 2014·Diseases of the Colon and Rectum·Francesco StipaCarlo Eugenio Vitelli
Dec 6, 2014·Hematology/oncology Clinics of North America·Angelita Habr-GamaRodrigo O Perez
Mar 17, 2015·International Journal of Radiation Oncology, Biology, Physics·Alberto ArezzoMario Morino
Apr 29, 2015·JAMA : the Journal of the American Medical Association·Lesley A StewartUNKNOWN PRISMA-IPD Development Group
Jul 12, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J E CuttingD E Messenger

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Citations

May 25, 2020·International Journal of Colorectal Disease·Konstantinos PerivoliotisGeorge Tzovaras
Jan 27, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Hester E HaakUNKNOWN Dutch Watch-and-Wait Consortium

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