Individual patient data meta-analysis of randomized evidence to assess the effectiveness of laparoscopic uterosacral nerve ablation in chronic pelvic pain.

Human Reproduction Update
Jane DanielsInternational LUNA IPD Meta-analysis Collaborative Group

Abstract

There have been conflicting results in randomized trials of the effects of laparoscopic uterosacral nerve ablation (LUNA) in chronic pelvic pain. Our objective was to perform a meta-analysis using individual patient data (IPD) to provide the most comprehensive and reliable assessment of the effectiveness of LUNA. Electronic searches were conducted in the Medline, Embase, PsycInfo and Cochrane Library databases from database inception to August 2009. The reference lists of known relevant papers were searched for any further articles. Randomized trials comparing LUNA with no additional intervention were selected and authors contacted for IPD. Raw data were available from 862 women randomized into five trials. Pain scores were calibrated to a 10-point scale and were analysed using a multilevel model allowing for repeated measures. There was no significant difference between LUNA and No LUNA for the worst pain recorded over a 12 month time period (mean difference 0.25 points in favour of No LUNA on a 0-10 point scale, 95% confidence interval: -0.08 to 0.58; P = 0.1). LUNA does not result in improved chronic pelvic pain.

References

Jul 1, 1992·American Journal of Obstetrics and Gynecology·G B CandianiG Di Nola
Mar 1, 1992·American Journal of Obstetrics and Gynecology·P N Baker, E M Symonds
Nov 1, 1990·Obstetrics and Gynecology·W J WatsonA S Aylsworth
Jul 1, 1990·British Journal of Obstetrics and Gynaecology·G SundellB Andersch
Dec 19, 1997·Fertility and Sterility·M G Porpora, V Gomel
Nov 5, 1999·British Journal of Obstetrics and Gynaecology·K T ZondervanS H Kennedy
Aug 30, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·F M Howard
Jul 27, 2001·Statistics in Medicine·J P HigginsS G Thompson
Mar 1, 2002·Evaluation & the Health Professions·Lesley A Stewart, Jayne F Tierney
Jul 1, 1955·American Journal of Obstetrics and Gynecology·J B DOYLE
Aug 26, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·N P JohnsonJ Suckling
Sep 17, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·P M LattheK S Khan
Jan 25, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Pallavi M LattheRichard Lilford
May 12, 2005·Statistics in Medicine·Rusty TchernisSharon-Lise T Normand
Feb 18, 2006·BMJ : British Medical Journal·Pallavi LattheKhalid Khan
May 6, 2006·BMJ : British Medical Journal·Douglas G Altman, Patrick Royston
Nov 13, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·T XiongUNKNOWN International LUNA IPD Meta-analysis Collaborative Group
Dec 7, 2007·The Journal of Pain : Official Journal of the American Pain Society·Robert H DworkinStojan Zavisic
Mar 4, 2009·Clinical Trials : Journal of the Society for Clinical Trials·Ashley P JonesAnne Whitehead
Sep 3, 2009·JAMA : the Journal of the American Medical Association·Jane DanielsUNKNOWN LUNA Trial Collaboration

❮ Previous
Next ❯

Citations

Jul 6, 2013·Systematic Reviews·Gerjon HanninkMaroeska M Rovers
Aug 27, 2014·Obstetrics and Gynecology Clinics of North America·M Brigid Holloran-Schwartz
Aug 7, 2012·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Priscilla D Abercrombie, Lee A Learman
Mar 10, 2016·Reproductive Health·Luciano MigniniUNKNOWN EBM-CONNECT Collaboration
Jun 21, 2015·Contemporary Clinical Trials·Mark SimmondsLesley Stewart
May 27, 2014·Human Reproduction Update·Matteo MorottiChristian M Becker
Jun 11, 2016·Current Opinion in Obstetrics & Gynecology·Sangeeta SenapatiMark Frank F Tu
May 12, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Alexis D GreeneKatherine A Burns
Nov 18, 2018·International Journal of Epidemiology·Ewoud SchuitJohn P A Ioannidis
Nov 7, 2014·Journal of General Internal Medicine·Megan R GerberSally G Haskell
Jan 8, 2018·Psychotherapy and Psychosomatics·Peter HenningsenFrancis Creed
Jun 10, 2020·Current Opinion in Obstetrics & Gynecology·Carmen Amezcua-PrietoKhalid Saed Khan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.