Individual sensitivity distribution evaluation from survival data using a mechanistic model: implications for ecotoxicological risk assessment

Chemosphere
Rémy BeaudouinA R R Péry

Abstract

Two main alternatives are typically used to model mechanistically dose-survival relationship in ecotoxicity tests. Effects are related to a concentration of concern, for instance body concentration, and, to account for their differences relative to time-to-death, individuals have either different concentration thresholds for death ("individual tolerance approach"), or equal probability to die, with death occurring randomly ("stochastic death approach"). A general framework to unify both approaches has recently been proposed. We derived a model from this framework to analyse five datasets (daphnids exposed to selenium, guppies exposed to dieldrin and second, third and fourth instars chironomids exposed to copper), by extending the standard stochastic death approach. We showed the possibility to estimate properly the toxicity parameters together with inter-organisms differences of sensitivity for at least one of these parameters (here the threshold for effect). For the daphnids, there was no improvement of using the extended model, which confirms the expected low variability among genetically identical individuals. For all the other datasets, our model outperformed the standard approach without accounting for differences of sensi...Continue Reading

References

Jan 1, 1994·Environmental Health Perspectives·W Slob, E I Krajnc
Sep 17, 2002·Water Research·A R PéryS A Kooijman
Feb 22, 2005·Environmental Toxicology and Chemistry·Lorraine MaltbyPaul J van den Brink
Dec 25, 2008·Environmental Toxicology and Chemistry·Valery E ForbesRichard M Sibly
Feb 6, 2009·Environmental Science & Technology·Elise BilloirSandrine Charles
Jul 28, 2009·Ecotoxicology·Erik B MullerHeather A Berkley
Feb 23, 2010·Regulatory Toxicology and Pharmacology : RTP·Alexandre R R PéryJ M Vincent
Sep 24, 2010·Journal of Environmental Monitoring : JEM·Roman Ashauer, Beate I Escher
Mar 4, 2011·Environmental Science & Technology·Tjalling JagerRoman Ashauer
Aug 2, 2011·Environmental Toxicology and Chemistry·Roman AshauerThomas G Preuss

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Citations

Jul 16, 2015·Environmental Science & Technology·Roman AshauerBeate I Escher
Jul 7, 2016·Scientific Reports·Roman AshauerThomas G Preuss

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