Individual tumorigenesis pathways of sporadic colorectal adenocarcinomas are associated with the biological behavior of tumors

Cancer Science
Jin C KimYong S Kim

Abstract

Clinicopathologic features of sporadic colorectal adenocarcinomas were compared using integrated data from 224 [corrected] patients subjected to curative resection. Individual steps in the tumorigenesis pathway, that is, adenomatosis polyposis coli (APC), Wnt-activated, base excision repair mutations, mismatch repair defects, RAF-mediated, transforming growth factor (TGF)-beta-suppressed, bone morphogenic protein (BMP)-suppressed, and p53 alterations, were examined in terms of genetic and epigenetic changes, as well as protein expression. Genetic and molecular alterations of right colon cancers were distinct from those of left colon and rectal cancers. Rectal cancers showed the attenuated phenotype of left colon cancers. Tumors most frequently displayed either TGF-beta- or BMP-suppressed alterations (81.2%), followed by RAF-mediated alterations (78.6%), and mismatch repair defects (38.4%), constituting a total of 24 integrated pathways. Tumors lacking APC mutations or carrying the RAF alteration (V600E) were frequently associated with lymphovascular invasion and lymph node metastasis (P < 0.05). Poorly differentiated or mucinous adenocarcinomas were generally associated with high level microsatellite instability, Axin2 suppress...Continue Reading

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Citations

Jul 3, 2009·Diseases of the Colon and Rectum·Martha L SlatteryWade Samowitz
May 28, 2011·Journal of Gastroenterology and Hepatology·Yong Sik YoonJin Cheon Kim
May 26, 2011·PloS One·Whitney G Smalley-FreedAlbert B Reynolds
Nov 27, 2008·World Journal of Gastroenterology : WJG·Jin-Cheon KimYong-Sung Kim
Nov 17, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jochen GaedckeMichael Ghadimi
Mar 2, 2010·Journal of Korean Medical Science·Seon Ae RohJin Cheon Kim
Aug 21, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Tomiyo NakamuraNariaki Matsuura
Dec 13, 2019·ANZ Journal of Surgery·Steven R ParedesMatthew J F X Rickard
May 31, 2016·World Journal of Gastroenterology : WJG·Petra MinarikovaMarek Minarik

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