Individual variability in the recall of fear extinction is associated with phosphorylation of mitogen-activated protein kinase in the infralimbic cortex

Psychopharmacology
Amanda S RussoRyan G Parsons

Abstract

Although most individuals will be exposed to trauma at some point, only a small portion of individuals develops posttraumatic stress disorder (PTSD), suggesting there are factors which render some individuals particularly susceptible to the development of this disorder. One cardinal feature of PTSD is the failure to extinguish fear responses to cues that once signaled danger. Rodent studies of fear learning and extinction have provided insight into the neural mechanisms underlying extinction; however, most of these studies have focused on mechanisms involved in typical responses and fewer have identified mechanisms that distinguish animals that extinguish well versus those that do not extinguish their fear responses. Investigation of individual differences in fear extinction might help us better understand the susceptibility to and development of PTSD. In order to understand the neural mechanisms underlying such variation, we assessed phosphorylated mitogen-activated protein kinase (P-MAPK) levels in infralimbic cortex (IL), basolateral amygdala (BLA), and dorsal hippocampus in subsets of rats which exhibited good or poor recall of extinction. We found a relationship between extinction recall and P-MAPK in the IL such that rats...Continue Reading

References

Dec 1, 1995·Archives of General Psychiatry·R C KesslerC B Nelson
Jul 22, 1998·Archives of General Psychiatry·N BreslauP Andreski
Nov 8, 2002·Nature·Mohammed R Milad, Gregory J Quirk
Mar 6, 2004·Annals of the New York Academy of Sciences·Barbara Olasov Rothbaum, Michael Davis
Oct 7, 2004·Learning & Memory·Kelimer LebrónGregory J Quirk
Aug 3, 2006·The European Journal of Neuroscience·Cyril HerryNicole Mons
Sep 29, 2006·The European Journal of Neuroscience·Demetrio Sierra-MercadoGregory J Quirk
Nov 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephen Maren, Chun-hui Chang
Dec 13, 2006·Molecular Psychiatry·K M Myers, M Davis
Aug 28, 2007·Journal of Traumatic Stress·David E A BushJoseph E LeDoux
Sep 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregory J Quirk, Devin Mueller
Mar 4, 2008·Journal of Psychiatric Research·Mohammed R MiladRoger K Pitman
Aug 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kathryn HefnerAndrew Holmes
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Natalie C TronsonJelena Radulovic
Sep 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jee Hyun KimRick Richardson
Sep 15, 2009·Biological Psychiatry·Mohammed R MiladScott L Rauch
Jun 5, 2010·Science·Jamie PetersGregory J Quirk
Jul 20, 2010·Current Biology : CB·Brian J WiltgenAlcino J Silva
Aug 27, 2010·Frontiers in Behavioral Neuroscience·Ryan G ParsonsFred J Helmstetter
Nov 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caitlin A OrsiniStephen Maren
Dec 2, 2011·Annual Review of Psychology·Mohammed R Milad, Gregory J Quirk
Oct 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ewelina KnapskaLeszek Kaczmarek
Nov 28, 2012·Neuron·Francisco Sotres-BayonGregory J Quirk
Dec 25, 2012·Trends in Neurosciences·Andrew Holmes, Nicolas Singewald
Jan 29, 2013·Nature Neuroscience·Ryan G Parsons, Kerry J Ressler
May 3, 2013·Nature Reviews. Neuroscience·Stephen MarenIsrael Liberzon
Jan 1, 2014·Brain Research Bulletin·Paul J FitzgeraldStephen Maren
May 6, 2014·Animal Cognition·Jason ShumakeMarie H Monfils
Jan 21, 2015·Nature·Fabricio H Do-MonteGregory J Quirk
Feb 27, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fabricio H Do-MonteGregory J Quirk
Sep 12, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hyung-Su KimJin-Hee Han

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Methods Mentioned

BETA
dissection
Protein Assay
electrophoresis

Software Mentioned

Image Lab
ChemiDoc
FreezeScan

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