PMID: 1204209Dec 1, 1975Paper

Individual variation in inosine triphosphate accumulation in human erythrocytes

Clinical Biochemistry
J H FraserE E McCoy

Abstract

Erythrocytes from 5% of a normal population accumulated relatively high amounts of radioactive inosine triphosphate (i.e., greater than 70 nmoles/10(10) cells in 2 hr) when they were incubated with [14C]hypoxanthine. The incidence of this characteristic in a mentally retarded population was 16%. Inosine triphosphate was synthesized from [14C]hypoxanthine, but not from [14C]adenine or [14C]guanine. The metabolism of [14C]adenine and [14C]guanine was the same in erythrocytes that accumulated "normal" and "high" amounts of inosine triphosphate. Inosine triphosphate did not accumulate in leukocytes.

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Citations

Jan 1, 1990·Parasitology Research·C MatiasA M Gero
Jul 26, 1979·Biochimica Et Biophysica Acta·J M Whelan, A S Bagnara
Feb 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·G van WaegC H de Verdier
May 1, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·J A DuleyR J Levinsky
Jun 11, 2005·Molecular Genetics and Metabolism·Tohru MaedaHajime Togari
Nov 10, 2012·World Journal of Gastroenterology : WJG·Akihito TsubotaYoshio Aizawa
Oct 11, 2007·Pharmacogenomics·Jörgen BierauJaap A Bakker
Aug 22, 2006·Alimentary Pharmacology & Therapeutics·L J J DerijksD W Hommes
Oct 28, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Naoya SakamotoMamoru Watanabe
Oct 12, 2013·Pharmacotherapy·Marina Kawaguchi-Suzuki, Reginald F Frye
Jan 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laurence J EganDaniel W Hommes
Jun 13, 2015·Pharmacogenomics·Rebecca L Roberts, Murray L Barclay
Nov 23, 2006·Biochimica Et Biophysica Acta·Monica ArenasAnthony Marinaki
Jul 8, 2017·Pharmacogenomics·Sara RufiniPaola Borgiani
Jun 1, 1979·Journal of Cellular Physiology·B S Vanderheiden
Apr 10, 2014·Therapeutic Drug Monitoring·Antony Citterio-QuentinRoselyne Boulieu
Feb 17, 2007·Therapeutic Drug Monitoring·Srebrena AtanasovaNicolas von Ahsen
Jan 1, 1984·Scandinavian Journal of Haematology·L J HallamM G Whiteside
May 1, 2008·Personalized Medicine·Rebecca L RobertsMurray L Barclay

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