Individual variation in the frequency of HLA class II-specific cytotoxic T lymphocyte precursors

European Journal of Immunology
S ManC E Sharrock

Abstract

The frequencies of HLA class II-specific cytotoxic T lymphocyte precursors (CTLp) were studied in number of unrelated individuals using a limiting dilution analysis system optimized for the detection of CD4+ CTLp. Peripheral blood mononuclear cells (PBMC) were enriched for CD4+ T cells by immunomagnetic depletion of CD8+ T cells. In some allogeneic combinations high CTLp frequencies were obtained with no significant difference between PBMC and CD4-enriched PBMC populations. In other combinations CTLp frequencies in CD4-enriched PBMC were found to be at least twentyfold lower than in the starting, unfractionated PBMC, suggesting a predominance in these pairs of CD8+ CTLp. In addition there was variation in CTLp frequencies against the same set of HLA class II gene products between individuals, and variation in CTLp frequencies against different HLA class II gene products within individuals. The HLA class II specificity of the assay system was demonstrated unequivocally with detection of CTLp against HLA-DR1 expressed on a murine L cell transfectant.

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Citations

Oct 30, 1999·Clinical and Experimental Immunology·G XanthouH M Moutsopoulos
Nov 20, 2013·Seminars in Immunology·Hilde Cheroutre, Mohammad Mushtaq Husain
Sep 18, 2004·Clinical and Experimental Immunology·V Appay
Aug 12, 2006·Journal of Viral Hepatitis·N AslanH Wedemeyer
Jul 20, 2010·International Reviews of Immunology·Debora MartorelliRiccardo Dolcetti
Mar 16, 2017·Frontiers in Immunology·Elena MuraroAntonio Rosato
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M EvansS Man
Apr 5, 2019·British Journal of Haematology·Stephen Man, Peter Henley
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor AppayAnthony D Kelleher
Aug 28, 2021·International Journal of Molecular Sciences·Milica Perišić NanutJanko Kos

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