PMID: 6108768Apr 1, 1980Paper

Individual variation of nucleoside triphosphate pyrophosphohydrolase activity in human erythrocytes, granulocytes, lymphocytes, and platelets

Biochemical Genetics
V L VerhoefA J Morris

Abstract

Analysis of the nucleoside triphosphate pyrophosphohydrolase specific activity of red cells obtained from a random Caucasian population indicated at least two subclasses. The specific activity of 18% of the population ranged from undetectable activity to 27.5 nmol ITP cleaved/20 min/mg hemoglobin. The remainder of the population had higher activity, 27.5-125 nmoles ITP cleaved/20 min/mg hemoglobin. The variation of NTPH activity evident in the red cells of an individual is reflected in granulocytes, lymphocytes, and platelets of that individual. Erythrocyte activity ranges from 0.7 to 21 units (nmol of ITP cleaved in 20 min)/10(7) cells, granulocytes have 17-201 units/10(7) cells, lymphocytes have 91-462 units/10(7) cells, and platelets have 1.1-7.1 units/10(7) platelets. These cell differences are discussed with respect to the hypothesis that NTPH prevents incorporation of ITP or dITP into nucleic acids.

References

Apr 1, 1977·Canadian Journal of Biochemistry·J F HendersonA J Morris
Aug 1, 1975·Journal of Cellular Physiology·B S Vanderheiden
Dec 1, 1975·Clinical Biochemistry·J H FraserE E McCoy
Sep 22, 1970·Biochimica Et Biophysica Acta·B S Vanderheiden
Jun 1, 1969·Biochemical Genetics·B S Vanderheiden

❮ Previous
Next ❯

Citations

Mar 27, 2013·Journal of Structural Biology·Peter D SimoneGloria E O Borgstahl
Apr 14, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Wim H M VroemenMathie P G Leers
Oct 12, 2012·Environmental and Molecular Mutagenesis·Irina S-R WaisertreigerYouri I Pavlov
Feb 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karolina RembeckMartin Lagging
Oct 25, 2016·Journal of Biomedical Science·Nicholas E Burgis
Jun 1, 2004·Inflammatory Bowel Diseases·William J Sandborn
Jun 24, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·David P BreenPeter C Hayes
Dec 1, 1985·Arthritis and Rheumatism·J W Rachow, L M Ryan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.